Chronic infection and malignancy screening in Mexican patients with multiple sclerosis.
Objective: Screening studies are recommended to rule out neoplasms and chronic infections before starting disease-modifying therapies (DMTs). To illustrate the importance of screening before DMT initiation and to show, the most frequent findings in patients with multiple sclerosis (MS) in a developi...
| Publicado en: | Revista Mexicana de Neurociencia Vol. 26; no. 2; pp. 43 - 49 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
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Academia Mexicana de Neurologia
Mar/Apr2025
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=185017047&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 185017047 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 16655044 R1Q jtl: Revista Mexicana de Neurociencia issn: 16655044 maglogo: N pubinfo: dt: Mar/Apr2025 vid: 26 iid: 2 pid: 20851 pub: Academia Mexicana de Neurologia artinfo: ui: 185017047 10.24875/RMN.24000016 ppf: 43 ppct: 6 formats: fmt: @attributes: type: P size: 300KB tig: atl: Chronic infection and malignancy screening in Mexican patients with multiple sclerosis. aug: au: Zertuche-Ortuño, Lizeth Rivera-Sarabia, Linda García-Ramírez, Juan J. Hernández-Castillo, Víctor Treviño-Frenk, Irene affil: Department of Neurology, Multiple Sclerosis Clinic, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Mexico City, Mexico su: Sexually transmitted diseases Human papillomavirus HIV Penile cancer Papillomavirus diseases sug: subj: Sexually transmitted diseases Human papillomavirus HIV Penile cancer Papillomavirus diseases keyword: Chronic infections Multiple sclerosis Prevention Screening Treatment initiation Esclerosis múltiple Infecciones crónicas Inicio del tratamiento Prevención Tamizaje ab: Objective: Screening studies are recommended to rule out neoplasms and chronic infections before starting disease-modifying therapies (DMTs). To illustrate the importance of screening before DMT initiation and to show, the most frequent findings in patients with multiple sclerosis (MS) in a developing country. Methods: We analyzed patients admitted to the MS clinic from 2020 to 2023 who underwent screening before the initiation of DMT. All patients were sampled for: quantiFERON for tuberculosis (TB), varicella zoster immunoglobulin G levels, human immunodeficiency virus, Hepatitis B, Hepatitis C virus, venereal disease research laboratory, papanicolaou smear, and mammogram in women over 40. Results: We analyzed 103 patients, 74 of whom were women (71.8%), with a mean age of 42.8 ± 15. Pathological findings were detected in 21 (20%) patients: latent TB in 12 (11.6%), cervical human papillomavirus infection in 3 (2.9%), benign thyroid nodule in 2 (1.9%), liver TB in 1 (0.9%), penile squamous carcinoma in 1 (0.9%), thyroid carcinoma in 1 (0.9%), and breast papilloma in 1 (0.9%). Patients who received DMT did not develop any complications. Conclusions: The pathological findings did not influence the final treatment decision. However, screening tests are essential for the early detection and management of chronic conditions. Conducting these tests before initiating DMTs helps identify potential comorbidities or contraindications to immunosuppressive treatments, ensuring safer and more effective patient care. Objetivo: Los estudios de cribado se recomiendan para descartar neoplasias e infecciones crónicas antes de las terapias modificadoras de la enfermedad. (TME). Ilustrar la importancia del cribado previo al inicio de TME, mostrar los hallazgos más frecuentes en pacientes con esclerosis multiple (EM) en un país en vías de desarrollo. Métodos: Se analizaron los pacientes ingresados en la consulta de EM entre 2020-2023, a quienes se les realizó un perfilamiento previo al inicio de TME. A todos los pacientes se les tomaron muestras de: quantiFERON para tuberculosis, niveles de IgG varicela zoster, virus de la inmunodeficiencia humana, hepatitis B, hepatitis C, VDRL, citología vaginal y mamografía en mujeres mayores de 40 años. Resultados: Se analizaron 103 pacientes, de los cuales 74 eran mujeres (71.8%), la edad media fue de 42.8 ± 15 años. Se detectaron hallazgos patológicos en 21 (20%) pacientes: tuberculosis latente 12 (11.6%), infección cervical por VPH 3 (2.9%), nódulo tiroideo benigno 2 (1.9%), tuberculosis hepática 1 (0.9%), carcinoma escamoso de pene 1 (0.9%), carcinoma de tiroides 1 (0.9%) y papiloma de mama 1 (0.9%). Los pacientes que recibieron TME no desarrollaron ninguna complicación. Conclusiones: Los hallazgos patológicos no influyeron en la decisión final del tratamiento. Sin embargo, el perfilamiento es esencial para la detección temprana y el tratamiento de enfermedades crónicas. La realización de estas pruebas ayuda a identificar posibles comorbilidades o contraindicaciones para los tratamientos inmunosupresores, lo que garantiza una atención al paciente más segura y eficaz. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Revista Mexicana de Neurociencia is the property of Academia Mexicana de Neurologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Revista Mexicana de Neurociencia holder: Academia Mexicana de Neurologia dt: @attributes: year: 2025 holdings: @attributes: islocal: N |
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