Efficacy of a Rehabilitation Treatment Using Action Observation Therapy Enhanced by Muscle Synergy-Derived Electrical Stimulation (OTHELLO) in Post-Stroke Patients: A RCT Study Protocol.
Background: Action Observation Therapy (AOT) and Neuromuscular Electrical Stimulation (NMES) are widely adopted techniques for upper-limb rehabilitation in post-stroke patients. Although AOT and NMES are individually effective, studies investigating a potential synergistic effect on enhancing rehabi...
| Publicado en: | Journal of Central Nervous System Disease pp. 1 - 12 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | protocol tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
5/11/2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=185098353&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 185098353 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11795735 B3L8 jtl: Journal of Central Nervous System Disease issn: 11795735 maglogo: Y pubinfo: dt: 5/11/2025 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 185098353 185098353 185098353 10.1177/11795735251331511 185098353 ppf: 1 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Efficacy of a Rehabilitation Treatment Using Action Observation Therapy Enhanced by Muscle Synergy-Derived Electrical Stimulation (OTHELLO) in Post-Stroke Patients: A RCT Study Protocol. aug: au: Cabinio, Monia Lencioni, Tiziana Nuara, Arturo Rossetto, Federica Blasi, Valeria Bailo, Gaia Cardini, Rebecca Bertoni, Rita Viganò, Alessandro Bianco, Mariangela Comanducci, Angela Avanzini, Pietro Ferrarin, Maurizio Fornia, Luca Baglio, Francesca affil: 9360 IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy sug: subj: Stroke Rehabilitation Rehabilitation, Cognitive Electrical Stimulation, Neuromuscular Combined Modality Therapy Treatment Outcomes Neuromuscular Control Motor Skills Evaluation Functional Assessment Recovery Upper Extremity Physiology Randomized Controlled Trials ab: Background: Action Observation Therapy (AOT) and Neuromuscular Electrical Stimulation (NMES) are widely adopted techniques for upper-limb rehabilitation in post-stroke patients. Although AOT and NMES are individually effective, studies investigating a potential synergistic effect on enhancing rehabilitative outcomes are lacking. Objectives: This study aims at comparing the effect of AOT and NMES applied together (AOT-NMES) on muscle synergies with respect to either AOT alone or a Motor Neutral Observation treatment alone (MNO, involving neither AOT nor NMES) on motor function recovery of upper limb. Design: Randomized Controlled Trial (RCT) with n = 60 post-stroke patients with resulting upper limb disability, randomly allocated (1:1:1 ratio) in three interventional arms: AOT-NMES (n = 20), AOT (n = 20) and MNO (n = 20). Methods and Analyses: All rehabilitation treatments will consist of n°15 60 min-long rehabilitative sessions. Primary outcome measure will be upper limb motor function, assessed using the Fugl-Meyer Assessment scale for upper limb (FM-UL), collected at the baseline (T0), post-intervention (T1) and at follow-up (T2, 6-months after T1). Other outcome measures will be collected through a multidimensional evaluation including assessing stroke-associated quality of life, neurophysiological data, biomechanical and MRI measures. The innovative protocol will also be evaluated for usability and safety. Discussion: We expect to determine the efficacy, usability and safety of the AOT-NMES rehabilitation approach for the recovery of upper limb motor function in post-stroke patients. The obtained results will also help reveal the neural underpinnings of motor recovery, as assessed by neurophysiological data, biomechanical and MRI measures. pubtype: Academic Journal doctype: protocol tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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