A comparison of the effect of omega-3 alone versus omega-3/Vitamin D3 co-supplementation therapy on 25-hydroxyvitamin D levels in adults with vitamin D deficiency.
Background: Omega-3 fatty acid (n-3FA) supplementation may improve total hydroxyvitamin D (25OHD) levels in people with normal or low vitamin D levels. However, there was no agreement on the potential therapeutic benefit of n-3FA on vitamin D toxicity. Objective: The current randomized controlled cl...
| Publicado en: | Pharmacy Practice (1886-3655) Vol. 23; no. 1; pp. 1 - 10 |
|---|---|
| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Centro de Investigaciones y Publicaciones Farmaceuticas S.L.
Jan-Mar2025
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=185112640&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 185112640 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1885642X 3EAU jtl: Pharmacy Practice (1886-3655) issn: 1885642X maglogo: N pubinfo: dt: Jan-Mar2025 vid: 23 iid: 1 pid: 36266 pub: Centro de Investigaciones y Publicaciones Farmaceuticas S.L. artinfo: ui: 185112640 185112640 185112640 10.18549/PharmPract.2025.1.3050 185112640 ppf: 1 ppct: 9 formats: fmt: @attributes: type: P tig: atl: A comparison of the effect of omega-3 alone versus omega-3/Vitamin D3 co-supplementation therapy on 25-hydroxyvitamin D levels in adults with vitamin D deficiency. aug: au: Mohammad, Beisan A. Oriquat, Ghaleb Ali Khader, Heba A. Farah, Husni Shukri Alsayed, Ahmad R. Alhmoud, Jehad F. Al-Najjar, Mohammad A. A. Hasoun, Luai Abdelhalim, Shaimaa M. Awwad, Shady Abu-Samak, Mahmoud S. affil: Harmaceutical Sciences Department- PharmD Program, Fakeeh College for Medical Sciences, Jeddah 21461, Saudi Arabia sug: subj: Fatty Acids, omega-3 Adverse Effects Fatty Acids, omega-3 Therapeutic Use Cholecalciferol Therapeutic Use Dietary Supplementation Drug Therapy, Combination Vitamin D Blood Biological Markers Blood Vitamin D Deficiency Drug Therapy Drug Efficacy Human Jordan Funding Source Randomized Controlled Trials Random Assignment Male Female Adult Middle Age Fatty Acids, omega-3 Administration and Dosage Cholecalciferol Administration and Dosage After Care Parathyroid Hormones Blood Calcium Blood Leptin Blood Descriptive Statistics Cardiovascular Risk Factors COVID-19 Risk Factors Risk Assessment Hypervitaminosis Complications Overdose Complications Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: Omega-3 fatty acid (n-3FA) supplementation may improve total hydroxyvitamin D (25OHD) levels in people with normal or low vitamin D levels. However, there was no agreement on the potential therapeutic benefit of n-3FA on vitamin D toxicity. Objective: The current randomized controlled clinical study (RCT) sought to determine if daily omega-3 fatty acid (n-3FA) supple-mentation affected 25-hydroxyvitamin D (25OHD) levels. Methods: One hundred and twenty Jordanians aged 22 to 55 were randomly allocated into three groups supplemented with the dose of 50,000 IU VD3 taken weekly (D3) alone, 300 mg n-3FA taken daily (n-3FA) alone, or their com-bination (50,000 IU VD3 taken weekly + 300 mg n-3FA taken daily (D+). In addition, fasting baseline and follow-up (ten weeks; eight weeks supplementation plus two weeks washout) of serum 25 hydroxyvitamin D (25OHD), parathyroid hormone (PTH), calcium, and leptin were assayed. Results: The n-3FA supplementation significantly decreased mean serum 25OHD levels (11.97±4.6 vs 16.5±4.8, P<0.001) compared with their peers in the D3 group who showed a significant increase in 25OHD levels (41.15±11.7 vs 19.34±6.8, P<0.001). The follow-up PTH mean levels were pro-portionally accompanied by significant alterations of 25OHD levels in the two study groups. Conclusions: This novel RCT provides that eight weeks of n-3FA therapy significantly reduced 25OHD levels, which adverse effects may accompany vitamin D status and its health-related consequences, such as bone homeostasis, cardiovascular disease, and COVID-19 conditions. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|