Psychotropic polypharmacy impairs walking independence in post-stroke patients.
Purpose: Psychotropic drugs are associated with adverse outcomes in older adults. However, evidence on the effect of psychotropic use on walking ability in post-stroke patients is lacking. This study examined the association between psychotropic medication use and walking independence in post-stroke...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 81; no. 6; pp. 831 - 839 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=185155129&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 185155129 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Jun2025 vid: 81 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 185155129 184121742 185155129 185155129 10.1007/s00228-025-03833-7 185155129 ppf: 831 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Psychotropic polypharmacy impairs walking independence in post-stroke patients. aug: au: Matsumoto, Ayaka Yoshimura, Yoshihiro Nagano, Fumihiko Shimazu, Sayuri Bise, Takahiro Kido, Yoshifumi Shiraishi, Ai Kuzuhara, Aomi Hamada, Takenori Yoneda, Kouki affil: https://ror.org/00zpddd51 Center for Sarcopenia and Malnutrition Research, Kumamoto Rehabilitation Hospital, Kikuchi-County, 760 Magate, Kikuyo-Town, 869-1106, Kumamoto, Japan sug: subj: Stroke Rehabilitation Stroke Patients Psychotropic Drugs Therapeutic Use Polypharmacy Walking Evaluation Functional Assessment Human Female Male Aged Funding Source Retrospective Design Logistic Regression Hypnotics and Sedatives Adverse Effects Descriptive Statistics Prospective Studies Inpatients Japan Clinical Assessment Tools Aged: 65+ years Female Male ab: Purpose: Psychotropic drugs are associated with adverse outcomes in older adults. However, evidence on the effect of psychotropic use on walking ability in post-stroke patients is lacking. This study examined the association between psychotropic medication use and walking independence in post-stroke patients. Methods: This retrospective cohort study included stroke patients admitted for convalescent rehabilitation at a Japanese hospital between 2020 and 2022. Psychotropic medications (benzodiazepines, hypnotics, antipsychotics, and antidepressants) prescribed at admission were recorded. The primary outcome was walking independence at discharge, defined as a Functional Independence Measure (FIM) walk score ≥ 6. Logistic regression analyses examined the association between the number of psychotropic drugs and walking independence, adjusting for potential confounders. Results: Of the 709 patients enrolled, 559 (mean age 75.5 years, 52.8% male) were included in the analysis. At admission, 25.4% of patients used psychotropic drugs. In the adjusted analysis, the number of psychotropic medications was independently associated with lower walking independence at discharge (OR 0.620, 95% CI 0.428–0.897, P = 0.011). Hypnotic use specifically showed a negative impact on walking independence (OR 0.331, 95% CI 0.154–0.708, P = 0.004). However, psychotropic drug use was not significantly associated with improvement in FIM-motor scores. Conclusion: Psychotropic polypharmacy at admission, particularly with hypnotics, was associated with reduced likelihood of achieving walking independence after stroke rehabilitation. Judicious use of psychotropic medications may be warranted when ambulation is a critical goal for older post-stroke patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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