BSNEU-net: Block Feature Map Distortion and Switchable Normalization-Based Enhanced Union-net for Acute Leukemia Detection on Heterogeneous Dataset.

Acute leukemia is characterized by the swift proliferation of immature white blood cells (WBC) in the blood and bone marrow. It is categorized into acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), depending on whether the cell-line origin is lymphoid or myeloid, respectively. Dee...

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Publicado en:Journal of Imaging Informatics in Medicine Vol. 38; no. 3; pp. 1334 - 1362
Autores principales: Saikia, Rabul, Deka, Roopam, Sarma, Anupam, Devi, Salam Shuleenda
Formato: equations & formulas pictorial research tables/charts Journal Article
Publicado: Springer Nature Jun2025
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jun2025
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s10278-024-01252-1
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        atl: BSNEU-net: Block Feature Map Distortion and Switchable Normalization-Based Enhanced Union-net for Acute Leukemia Detection on Heterogeneous Dataset.
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          Saikia, Rabul
          Deka, Roopam
          Sarma, Anupam
          Devi, Salam Shuleenda
        affil: https://ror.org/020vd6n84 Department of Electronics and Communication Engineering, National Institute of Technology Meghalaya, Shillong, India
      sug:
        subj:
          Leukemia, Lymphocytic, Acute Pathology
          Leukemia, Lymphocytic, Acute Blood
          Leukemia, Lymphocytic, Acute Diagnosis
          Hematologic Tests Methods
          Deep Learning Methods
          Image Interpretation, Computer Assisted Methods
          Neural Networks (Computer)
          Human
          Conceptual Framework
          Machine Learning Algorithms
          Diagnostic Imaging Methods
          Alanine Aminotransferase Blood
          Aspartate Aminotransferase Blood
          T-Tests
          Statistical Significance
          Data Analysis Software
          Descriptive Statistics
          Funding Source
      ab: Acute leukemia is characterized by the swift proliferation of immature white blood cells (WBC) in the blood and bone marrow. It is categorized into acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), depending on whether the cell-line origin is lymphoid or myeloid, respectively. Deep learning (DL) and artificial intelligence (AI) are revolutionizing medical sciences by assisting clinicians with rapid illness identification, reducing workload, and enhancing diagnostic accuracy. This paper proposes a DL-based novel BSNEU-net framework to detect acute leukemia. It comprises 4 Union Blocks (UB) and incorporates block feature map distortion (BFMD) with switchable normalization (SN) in each UB. The UB employs union convolution to extract more discriminant features. The BFMD is adapted to acquire more generalized patterns to minimize overfitting, whereas SN layers are appended to improve the model's convergence and generalization capabilities. The uniform utilization of batch normalization across convolution layers is sensitive to the mini-batch dimension changes, which is effectively remedied by incorporating an SN layer. Here, a new dataset comprising 2400 blood smear images of ALL, AML, and healthy cases is proposed, as DL methodologies necessitate a sizeable and well-annotated dataset to combat overfitting issues. Further, a heterogeneous dataset comprising 2700 smear images is created by combining four publicly accessible benchmark datasets of ALL, AML, and healthy cases. The BSNEU-net model achieved excellent performance with 99.37% accuracy on the novel dataset and 99.44% accuracy on the heterogeneous dataset. The comparative analysis signifies the superiority of the proposed methodology with comparing schemes.
      pubtype: Academic Journal
      doctype:
        equations & formulas
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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