Predictive Value of Left Atrial Structure and Function Parameters in Left Ventricular Remodeling in Patients With Type 2 Diabetes Mellitus.
Background: The 4‐dimensional automated left atrial quantification (4D Auto LAQ) technology for the left atrium was recently available. We aimed to evaluate LA function using 4D Auto LAQ in patients with type 2 diabetes mellitus (T2DM) and investigate its value in predicting left ventricular remodel...
| Publicado en: | Echocardiography Vol. 42; no. 5; pp. 1 - 10 |
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| Autores principales: | , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
May2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=185414302&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 185414302 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07422822 GSE jtl: Echocardiography issn: 07422822 maglogo: Y pubinfo: dt: May2025 vid: 42 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 185414302 185414302 185414302 10.1111/echo.70196 185414302 ppf: 1 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Predictive Value of Left Atrial Structure and Function Parameters in Left Ventricular Remodeling in Patients With Type 2 Diabetes Mellitus. aug: au: Xing, Yumeng Zhao, Rui Zhang, Xiaoli Jin, Jiamei Yang, Yiming Wang, Haier Wang, Yan Zhong, Chunyan Chen, Lin Zhang, Yinjia affil: Department of Ultrasound, Huadong Hospital, Fudan University, Shanghai, China sug: subj: Diabetes Mellitus, Type 2 Complications Heart Atrium, Left Physiology Heart Atrium, Left Anatomy and Histology Echocardiography Methods Predictive Value of Tests Heart Ventricle, Left Ventricular Remodeling Risk Factors Risk Assessment Human Male Female Diabetic Patients China Comparative Studies Descriptive Statistics Odds Ratio ROC Curve Funding Source Male Female ab: Background: The 4‐dimensional automated left atrial quantification (4D Auto LAQ) technology for the left atrium was recently available. We aimed to evaluate LA function using 4D Auto LAQ in patients with type 2 diabetes mellitus (T2DM) and investigate its value in predicting left ventricular remodeling (LVR). Methods: A total of 106 T2DM patients (56 with left ventricular [LV] remodeling and 50 with normal geometry) and 46 age‐ and sex‐matched controls were enrolled. LA total emptying fraction (LATEF), LA active emptying fraction (LAAEF), LA passive emptying fraction (LAPEF), and strain parameters, including LA reservoir longitudinal/circumferential strain (LASr/LASr‐c), LA conduit longitudinal/circumferential strain (LAScd/LAScd‐c), and LA contraction longitudinal/circumferential strain (LASct/LASct‐c), were assessed with 4D Auto LAQ. Results: Compared to controls, LASr, LAScd, and LAPEF significantly decreased in both groups of T2DM patients (p < 0.001). T2DM patients with LVR had significantly lower LASr and LAScd than those with normal geometry (p < 0.001). LATEF was also reduced in T2DM patients with LVR compared to the control group (p < 0.05). Among the 4D‐LAQ parameters, only LASr (odds ratio [OR]: 0.860, p = 0.016) was associated with LV remodeling (LVR) in multivariate analysis. Receiver operating characteristic (ROC) curves identified a LASr value of ≤22.5% as the optimal cutoff point to predict LVR in the T2DM cohort (sensitivity, 86.0%; specificity, 64.3%; area under the curve [AUC], 0.770; p < 0.001). In addition, LASr was found to be negatively correlated with both LV mass index (LVMI) and relative wall thickness (RWT) but positively correlated with the absolute value of the LV global longitudinal strain (LVGLS). Conclusions: Impairment of LA reservoir and conduit functions can be observed in patients with T2DM, particularly in those with LVR. LASr may serve as a predictor of LVR in patients with T2DM. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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