Causal Relationship between Omega-6/Omega-3 Fatty Acid Ratio and Risk of Lung Cancer: A Mendelian Randomization Study Base on A European Cohort.
Background: This study aimed to elucidate the causal relationship between Omega-6/Omega-3 fatty acid ratio and the risk of lung cancer by using Mendelian randomization (MR) analyses. Methods: Omega-6/Omega-3 fatty acid ratio data from the IEU database and lung cancer patient data from the Internatio...
| Publicado en: | Nutrition & Cancer Vol. 77; no. 6; pp. 666 - 675 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=185415894&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 185415894 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2025 vid: 77 iid: 6 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 185415894 184289679 185415894 185415894 10.1080/01635581.2025.2486151 185415894 ppf: 666 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Causal Relationship between Omega-6/Omega-3 Fatty Acid Ratio and Risk of Lung Cancer: A Mendelian Randomization Study Base on A European Cohort. aug: au: Li, Yue Liu, Jun Li, Guosheng Yan, Guanqiang Gao, Xiang Wei, Longqian Feng, Guiyu Xu, Zhanyu Yang, Nuo Zhou, Huafu affil: Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China sug: subj: Fatty Acids, omega-6 Analysis Fatty Acids, omega-3 Analysis Lung Neoplasms Risk Factors Risk Assessment Human Funding Source Europe Male Female Cancer Patients Mendelian Randomization Polymorphism, Single Nucleotide Models, Statistical Descriptive Statistics Male Female ab: Background: This study aimed to elucidate the causal relationship between Omega-6/Omega-3 fatty acid ratio and the risk of lung cancer by using Mendelian randomization (MR) analyses. Methods: Omega-6/Omega-3 fatty acid ratio data from the IEU database and lung cancer patient data from the International Lung Cancer Consortium were collected for this MR analyses. Single nucleotide polymorphisms (SNPs) associated with Omega-6/Omega-3 fatty acid ratio were collected as instrumental variables (IVs) with criteria of P < 5E-8, linkage disequilibrium R2 > 0.001 and clump distance < 10,000 kb. We used the inverse variance weighted (IVW) method as the primary method of MR analyses to evaluate the causal relationship between Omega-6/Omega-3 fatty acid ratio and lung cancer risk. Heterogeneity of the analyses was assessed by Cochran's Q test. Horizontal pleiotropy was evaluated by the intercept with the MR-Egger test. Results: 28 SNPs related to Omega-6/Omega-3 fatty acid ratio were selected as IVs in total. The MR analyses results showed that higher Omega-6/Omega-3 fatty acid ratio was associated with lower risk of lung cancer (P = 0.009). No statistical significance was observed for MR-Egger and simple mode methods (P > 0.05). No significant horizontal pleiotropy was detected by MR-Egger regression test (P = 0.73). Conclusion: Higher Omega-6/Omega-3 fatty acid ratio was associated with lower lung cancer risk. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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