Relación de LYVE-1 con biomarcadores inflamatorios y regenerativos: análisis comparativo en individuos sanos y pacientes con pancreatitis crónica.
OBJECTIVE: To analyze and compare the relationship between LYVE-1 and the inflammatory and regenerative biomarkers TFF-1, creatinine, REG-1A, REG-1B, and CA19-9 in healthy individuals and patients with chronic pancreatitis. MATERIALS AND METHODS: Analytical, cross-sectional study using secondary dat...
| Published in: | Medicina Interna de México Vol. 41; no. 5; pp. 275 - 284 |
|---|---|
| Main Author: | |
| Format: | Article |
| Published: |
Colegio de Medicina Interna de Mexico
may2025
|
| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=185439442&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 185439442 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 01864866 7KO jtl: Medicina Interna de México issn: 01864866 maglogo: N pubinfo: dt: may2025 vid: 41 iid: 5 pid: 20842 pub: Colegio de Medicina Interna de Mexico artinfo: ui: 185439442 10.24245/mim.v71iMayo.10254 ppf: 275 ppct: 9 formats: fmt: @attributes: type: P size: 606KB tig: atl: Relación de LYVE-1 con biomarcadores inflamatorios y regenerativos: análisis comparativo en individuos sanos y pacientes con pancreatitis crónica. aug: au: Guevara Tirado, Alberto affil: Médico cirujano, maestro en medicina en la Universidad Científica del Sur, Lima, Perú su: Statistical significance Chronic pancreatitis Early detection of cancer Rank correlation (Statistics) Pancreatic diseases sug: subj: Statistical significance Chronic pancreatitis Early detection of cancer Rank correlation (Statistics) Pancreatic diseases keyword: Biomarkers chronic Comparative Study Linear models Pancreatitis Biomarcadores enfermedades pancreáticas estudio comparativo modelos lineales pancreatitis crónica ab: OBJECTIVE: To analyze and compare the relationship between LYVE-1 and the inflammatory and regenerative biomarkers TFF-1, creatinine, REG-1A, REG-1B, and CA19-9 in healthy individuals and patients with chronic pancreatitis. MATERIALS AND METHODS: Analytical, cross-sectional study using secondary data from an open-access article reviewing the role of urinary biomarkers in the early detection of pancreatic cancer. Correlations between LYVE-1 and other biomarkers were analyzed using Spearman's correlation coefficient and multivariate linear regression models. The results were stratified by study group. RESULTS: A total of 119 healthy subjects and 183 patients with pancreatitis were analyzed. In the former, the correlations of LYVE-1 were: REG-1B (rho = 0.544; p < 0.001), REG-1A (rho = 0.553; p < 0.001), TFF-1 (rho = 0.464, p < 0.001), creatinine (rho = 0.282, p = 0.002), CA19-9 (rho = 0.343; p = 0.006). In patients with pancreatitis: TFF-1 (rho = 0.725; p < 0.001), creatinine (r = 0.659; p < 0.001), REG-1B (rho = 0.459; p < 0.001). REG-1A (rho = 0.492; p < 0.001) and plasma CA19-9 (rho = 0.410; p < 0.001). In chronic pancreatitis, the regression model showed that REG-1B (B = 0.012; p = 0.003) was the only factor associated with LYVE-1, with an R of 0.386. The model was statistically significant (F = 4.778; p = 0.002). CONCLUSIONS: LYVE-1 shows distinct patterns of association with biomarkers of regeneration, inflammation, and organ dysfunction in healthy individuals and patients with pancreatitis. Its dynamic role, adapted to homeostatic or inflammatory contexts, positions it as an integral biomarker for the assessment and monitoring of pancreatitis and its systemic complications. OBJETIVO: Analizar y comparar la relación entre LYVE-1 y los biomarcadores inflamatorios y regenerativos TFF-1, creatinina, REG-1A, REG-1B y CA19-9 en individuos sanos y en pacientes con pancreatitis crónica. MATERIALES Y MÉTODOS: Estudio analítico y transversal en el que se utilizaron datos secundarios provenientes de un artículo de acceso abierto que revisó el papel de los biomarcadores urinarios en la detección temprana del cáncer de páncreas. Se analizaron las correlaciones entre LYVE-1 y otros biomarcadores mediante el coeficiente de correlación de Spearman y modelos de regresión lineal multivariada. Los resultados se estratificaron por grupo de estudio. RESULTADOS: Se analizaron 119 sujetos sanos y 183 pacientes con pancreatitis. En los primeros las correlaciones de LYVE-1 fueron: REG-1B (rho = 0.544; p < 0.001), REG-1A (rho = 0.553; p < 0.001), TFF-1 (rho = 0.464, p < 0.001), creatinina (rho = 0.282, p = 0.002), CA19-9 (rho = 0.343; p = 0.006). En los pacientes con pancreatitis: TFF-1 (rho = 0.725; p < 0.001), creatinina (r = 0.659; p < 0.001), REG-1B (rho = 0.459; p < 0.001). REG-1A (rho = 0.492; p < 0.001) y CA19-9 plasmático (rho = 0.410; p < 0.001). En pancreatitis crónica, el modelo de regresión mostró que REG-1B (B = 0.012; p = 0.003) fue el único factor asociado con LYVE-1, con un R² de 0.386. El modelo fue estadísticamente significativo (F = 4,778; p = 0.002). CONCLUSIONES: LYVE-1 muestra patrones diferenciados de asociación con biomarcadores de regeneración, inflamación y disfunción orgánica en individuos sanos y en pacientes con pancreatitis. Su papel dinámico, adaptado a contextos homeostáticos o inflamatorios, lo posiciona como un biomarcador integral para la evaluación y seguimiento de la pancreatitis, así como de sus complicaciones sistémicas. pubtype: Academic Journal doctype: Article src: R language: Spanish refInfo: copyright: @attributes: flag: Y custom: Copyright of Medicina Interna de México is the property of Colegio de Medicina Interna de Mexico and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Medicina Interna de México holder: Colegio de Medicina Interna de Mexico dt: @attributes: year: 2025 holdings: @attributes: islocal: N |
|---|