Enrichment of Microbial DNA in Plasma to Improve Pathogen Detection in Sepsis: A Pilot Study.

Background Diagnosis of sepsis and timely identification of pathogens in critically ill patients remains challenging. Plasma metagenomic sequencing to detect microbial cell-free DNA (mDNA) has shown promise, but low abundance of mDNA in plasma limits sensitivity and necessitates high sequencing dept...

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Bibliographic Details

Published in:	Clinical Chemistry Vol. 71; no. 5; pp. 567 - 577
Main Authors:	Dominguez, Eddie G, McDonald, Bradon R, Zhang, Haikun, Stephens, Michelle D, Dietmann, Elise C, Nedden, Megan, Byington, Nicole, Thompson, Sydney, Junak, Mary, Pepperell, Caitlin S, Kisat, Mehreen T
Format:	Journal Article
Published:	Oxford University Press / USA May2025
Online Access:	View this record in EBSCOhost