Structural and functional whole brain changes in autism spectrum disorder at different age stages.
Autism spectrum disorder (ASD) is a developmental disorder involving regional changes and local neural disturbances. However, few studies have investigated the dysfunctional phenomenon across different age stages. This study explores the structural and functional brain changes across different devel...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 34; no. 5; pp. 1589 - 1603 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
May2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=185519994&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 185519994 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: May2025 vid: 34 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 185519994 180166125 185519994 185519994 10.1007/s00787-024-02585-6 185519994 ppf: 1589 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Structural and functional whole brain changes in autism spectrum disorder at different age stages. aug: au: Wang, Zedong Zheng, Liqin Yang, Lijuan Yin, Shunjie Yu, Shiqi Chen, Kai ZHANG, TAO Wang, Hesong Zhang, Yong affil: https://ror.org/01vjw4z39 Microecology Research Center, Baiyun Branch, Nanfang Hospital, Southern Medical University, Guangzhou, China sug: subj: Brain Anatomy and Histology Brain Physiopathology Autism Spectrum Disorder In Infancy and Childhood Autism Spectrum Disorder In Adolescence Autism Spectrum Disorder In Adulthood Persons with Mental Disorders Funding Source Human Male Female Child Adolescence Adult Neuroradiography Parietal Lobe Basal Ganglia Prefrontal Cortex Thalamus One-Way Analysis of Variance Post Hoc Analysis T-Tests Data Analysis Software Descriptive Statistics Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Male Female ab: Autism spectrum disorder (ASD) is a developmental disorder involving regional changes and local neural disturbances. However, few studies have investigated the dysfunctional phenomenon across different age stages. This study explores the structural and functional brain changes across different developmental stages in individuals with ASD, focusing on childhood (6–12 years), adolescence (12–18 years), and adulthood (18 + years). Using a comprehensive set of neuroimaging metrics, including modulated and non-modulated voxel-based morphometry (VBM), regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional ALFF (fALFF), we identified significant stage-specific alterations in both VBM and functional measurements. Our results reveal that ASD is associated with progressive and stage-specific abnormalities in brain structure and function, with distinct patterns emerging at each developmental stage. Specifically, we observed significant modulated VBM reductions in the precuneus, lentiform nucleus, and inferior parietal lobule, accompanied by increases in the midbrain and sub-gyral regions. Moreover, we observed unmodulated VBM increment in regions including lentiform nucleus and thalamus. Functionally, ReHo analyses demonstrated disrupted local synchronization in the medial frontal gyrus, while ALFF and fALFF metrics highlighted altered spontaneous brain activity in the sub-gyral and sub-lobar. Finally, correlation analyses revealed that stage-specific findings are closely linked to clinical social- and behavior-related scores, with VBM in the inferior parietal lobule and putamen as well as ReHo in supplemental motor area being significantly associated with restrictive repetitive behaviors in childhood. These findings underscore the importance of considering age-specific brain changes when studying ASD and suggest that targeted interventions may be necessary at different developmental stages. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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