Rule-out and rule-in of carotid near-occlusion using color duplex ultrasound.

Purpose: Diagnosing carotid near-occlusion (CNO) with colour duplex ultrasound (CDU) is challenging. We hypothesised that CNO is associated with a reduced distal internal carotid artery (ICA) velocity and aimed to assess if distal velocity is able to diagnose CNO accurately. If not, we aimed to deve...

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Publicado en:Neuroradiology Vol. 67; no. 5; pp. 1223 - 1232
Autores principales: Skoog, Johan, Vanoli, Davide, Henze, Alexander, Fox, Allan J., Johansson, Elias
Formato: algorithm research tables/charts Journal Article
Publicado: Springer Nature May2025
Acceso en línea:Ver este registro en EBSCOhost
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      dt: May2025
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s00234-025-03612-2
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        atl: Rule-out and rule-in of carotid near-occlusion using color duplex ultrasound.
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        au:
          Skoog, Johan
          Vanoli, Davide
          Henze, Alexander
          Fox, Allan J.
          Johansson, Elias
        affil: https://ror.org/04vgqjj36 Department of Clinical Physiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden
      sug:
        subj:
          Carotid Stenosis Radiography
          Ultrasonography, Doppler, Color
          Human
          Prospective Studies
          Cross Sectional Studies
          Computed Tomography Angiography
          Descriptive Statistics
          Sensitivity and Specificity
          Blood Flow Velocity Evaluation
      ab: Purpose: Diagnosing carotid near-occlusion (CNO) with colour duplex ultrasound (CDU) is challenging. We hypothesised that CNO is associated with a reduced distal internal carotid artery (ICA) velocity and aimed to assess if distal velocity is able to diagnose CNO accurately. If not, we aimed to develop CDU rule-out and rule-in criteria to diagnose CNO. Methods: This is a prospective cross-sectional study in consecutive participants with suspected ≥ 50% carotid stenosis on CT angiography (CTA). CDU velocities in the common carotid artery, the stenosis and distal to the stenosis were examined. CTAs were assessed for CNO, serving as a reference test. If no CDU parameter was both sensitive and specific for CNO, rule-out (98% sensitive) and rule-in (99% specific) criteria were created. Results: Of the 315 included participants with ≥ 50% stenosis, 190 (60%) were conventional ≥ 50% stenosis and 125 (40%) CNO. No CDU parameter was both sensitive and specific for CNO. The best exclusion criteria were stenosis end diastolic velocity (EDV) ≤ 63 cm/s and/or distal peak systolic velocity (PSV) > 23 cm/s, seen in 115 (38%) participants. The best rule-in criteria were stenosis EDV ≥ 280 cm/s and/or distal PSV ≤ 23 cm/s, seen in 35 (12%) participants. Of the remaining participants, 143 (47%) were uncertain (74 CNOs) and 9 (3%) were misdiagnosed as carotid occlusion (all CNOs). Conclusions: CDU alone cannot diagnose CNO but can rule in or rule out CNO in half of participants with ≥ 50% stenosis. These criteria are intended for inclusion in an algorithm, sorting cases needing further exams, such as CTA and/or phase-contrast magnetic resonance angiography.
      pubtype: Academic Journal
      doctype:
        algorithm
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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