Predictors of Cryptococcus gattii Clinical Presentation and Outcome: An International Study.
Background Infection by Cryptococcus gattii can lead to pulmonary or central nervous system (CNS) disease, or both. Whether the sites of infection and disease severity are associated with C. gattii species and lineages or with certain underlying medical conditions, or both is unclear. We conducted a...
| Publicado en: | Clinical Infectious Diseases Vol. 80; no. 5; pp. 1088 - 1095 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
5/15/2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=185678772&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 185678772 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10584838 46X jtl: Clinical Infectious Diseases issn: 10584838 maglogo: N pubinfo: dt: 5/15/2025 vid: 80 iid: 5 pid: 622 pub: Oxford University Press / USA artinfo: ui: 185678772 185678772 185678772 10.1093/cid/ciae640 185678772 ppf: 1088 ppct: 7 formats: tig: atl: Predictors of Cryptococcus gattii Clinical Presentation and Outcome: An International Study. aug: au: Galanis, Eleni MacDougall, Laura Rose, Caren Chen, Sharon C A Oltean, Hanna N Cieslak, Paul R DeBess, Emilio Chong, Mei Sorrell, Tania C Baddley, John W Hoang, Linda M N Lockhart, Shawn R Pappas, Peter G Phillips, Peter affil: Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada sug: subj: Cryptococcosis Pathology Cryptococcosis Mortality Cryptococcus Mortality Risk Factors Risk Assessment Infection Treatment Outcomes Human Male Female Infant, Newborn Infant Child, Preschool Child Adolescence Adult Middle Age Aged Retrospective Design Record Review Prospective Studies Multiple Logistic Regression Comorbidity Odds Ratio Confidence Intervals Funding Source Lung Diseases Central Nervous System Diseases Infant, Newborn: birth-1 month Infant: 1-23 months Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background Infection by Cryptococcus gattii can lead to pulmonary or central nervous system (CNS) disease, or both. Whether the sites of infection and disease severity are associated with C. gattii species and lineages or with certain underlying medical conditions, or both is unclear. We conducted a retrospective cohort study to identify factors associated with site of infection and mortality among C. gattii cases. Methods We extracted data on 258 C. gattii cases from Australia, Canada, and the United States reported from 1999 to 2011. We conducted unadjusted and multivariable logistic regression analyses to evaluate factors associated with site of infection and C. gattii mortality among hospitalized cases (N = 218). Results Hospitalized C. gattii cases with CNS and other extrapulmonary disease were younger, more likely to reside in Australia, and be infected with variety gattii I (VGI) lineage but less likely to have comorbidities and die as compared to cases with pulmonary disease. The odds of having CNS and/or other extrapulmonary disease were 9 times higher in cases with VGI infection (adjusted odds ratio [aOR] = 9.21, 95% confidence interval [CI] = 3.28–25.89). Age ≥70 years (aOR = 6.69, 95% CI = 2.44–18.30), chronic lung disease (aOR = 2.62, 95% CI = 1.05–6.51) and an immunocompromised status (aOR = 2.08, 95% CI = 1.05–6.51) were associated with higher odds of C. gattii mortality. Conclusions Among hospitalized cases, C. gattii species and lineage are associated with site of infection but not with the risk of death, whereas older age and comorbidities increase the risk of death. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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