Post-COVID-19-pandemic changes and clinical characteristics of invasive group a streptococcal infections from 2015 to 2023.
Purpose: Since winter 2022, invasive GAS (iGAS) infections have re-emerged in Europe, causing severe diseases in children and adults. We aimed to examine whether this reported post-pandemic increase was associated with an increased disease severity and/or a shift in clinical disease phenotypes. Meth...
| Publicado en: | Infection Vol. 53; no. 3; pp. 991 - 1001 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=185686809&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 185686809 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Jun2025 vid: 53 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 185686809 180316235 185686809 185686809 10.1007/s15010-024-02413-8 185686809 ppf: 991 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Post-COVID-19-pandemic changes and clinical characteristics of invasive group a streptococcal infections from 2015 to 2023. aug: au: Tomidis Chatzimanouil, Markos K. Rößler, Susann Nurjadi, Dennis Iakovidis, Isidoros Berner, Reinhard Toepfner, Nicole Bornstein, the Dresden G. A. S. Study Group: Stefan Richard Aschoff, Roland Bornhäuser, Martin Güldner, Andreas Gunzer, Florian Herold, Johannes Schultz, Jurek Wimberger, Pauline Zahnert, Thomas affil: https://ror.org/042aqky30 Department of Pediatrics, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany sug: subj: COVID-19 Pandemic Adverse Effects Streptococcal Infections Symptoms Streptococcal Infections Trends Streptococcal Infections Drug Therapy Severity of Illness Clindamycin Therapeutic Use Immunoglobulins, Intravenous Therapeutic Use Mortality Prevention and Control Sepsis Mortality Toxic Shock Syndrome Mortality Human Tertiary Health Care Germany Phenotype Length of Stay Treatment Duration Child Adult Intensive Care Units, Pediatric Catecholamines Therapeutic Use Respiration, Artificial Descriptive Statistics Retrospective Design Record Review Child: 6-12 years Adult: 19-44 years ab: Purpose: Since winter 2022, invasive GAS (iGAS) infections have re-emerged in Europe, causing severe diseases in children and adults. We aimed to examine whether this reported post-pandemic increase was associated with an increased disease severity and/or a shift in clinical disease phenotypes. Methods: We performed detailed clinical phenotyping of patients hospitalized with iGAS infections at a 1410-bed tertiary German Medical Center from 01/2015 to 09/2023. Results: One hundred seventy-eight patients were included: 50 children (28.1%) and 128 adults (71.9%). IGAS infections of Q1/2023 exceeded the pre-pandemic average by 551% (1200% for children). The mean age of affected patients shifted significantly post-pandemically (49.5 ± 26.5 to 32.4 ± 28.2 years of age, p < 0.05), mainly due to the higher percentage of children affected with iGAS infections (15.2% pre-pandemic, 44.2% post-pandemic). CFR was significantly lower for children (2%) compared to adults (11.7%) (p < 0.05) and decreased from 13% to 6.5% post-pandemically (p = 0.148). Duration of antibiotic therapy (13.5 (10 to 21) to 10 (9 to 14) days), length of hospital (10 (4 to 25) to 7 (5 to 15) days), and ICU stay (7.0 (2.5 to 18.0) to 5.0 (3.0 to 8.5) days) were shorter post-pandemically. Despite the higher post-pandemic percentage of affected children, PICU admissions (57% before to 32% after), use of catecholamines (28.6% to 11.8%), invasive ventilation (35.7% to 17.6%) and CFR (7% to 0%) were all lower after the pandemic. Conclusion: Children were at higher risk for iGAS infections post-pandemically. The surge of post-pandemic iGAS infections was not accompanied by increased iGAS-associated morbidity and mortality. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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