Long COVID in Immunocompromised and Immunocompetent Patients: A Clinical, Morphologic, and Virologic Portrait.
Context.--Coronavirus disease 2019 (COVID) primarily affects the lung and can lead to chronic/post-COVID syndrome. Some insights about late pulmonary changes occurring in patients recovering from COVID have been published, but the evidence of detailed pathologic changes coming from follow-up care pa...
| Publicado en: | Archives of Pathology & Laboratory Medicine Vol. 149; no. 6; pp. 535 - 542 |
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| Autores principales: | , , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
College of American Pathologists
Jun2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=185710499&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 185710499 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039985 1FS jtl: Archives of Pathology & Laboratory Medicine issn: 00039985 maglogo: N pubinfo: dt: Jun2025 vid: 149 iid: 6 pid: 2550 pub: College of American Pathologists place: Northfield, Illinois artinfo: ui: 185710499 185710499 185710499 10.5858/arpa.2024-0043-OA 185710499 ppf: 535 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Long COVID in Immunocompromised and Immunocompetent Patients: A Clinical, Morphologic, and Virologic Portrait. aug: au: Ramalhosa, Fátima Lunardi, Francesca Bernardinello, Nicol Gori, Silvia Pezzuto, Federica Tauro, Veronica Del Vecchio, Claudia Giraudo, Chiara Balestro, Elisabetta Calabrese, Fiorella affil: Pathology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal sug: subj: Post-Acute COVID-19 Syndrome Immunology Post-Acute COVID-19 Syndrome Microbiology Post-Acute COVID-19 Syndrome Pathology Lung Anatomy and Histology Immunocompromised Host Immunocompetence Lung Transplantation Transplant Recipients Disease Attributes Biopsy Human Male Female Adult Middle Age Aged Aged, 80 and Over Retrospective Design Nonexperimental Studies Ambulatory Care Facilities Outpatients Comparative Studies Descriptive Statistics Pilot Studies Molecular Structure Correlational Studies Tomography, X-Ray Computed Lung Radiography Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Context.--Coronavirus disease 2019 (COVID) primarily affects the lung and can lead to chronic/post-COVID syndrome. Some insights about late pulmonary changes occurring in patients recovering from COVID have been published, but the evidence of detailed pathologic changes coming from follow-up care patients with long COVID is limited. Objective.--To evaluate tissue morphologic and viral features in transbronchial biopsies of long COVID patients (immunocompetent and immunocompromised). Design.--This retrospective observational study included 18 patients (9 immunocompetent and 9 immunocompromised) who were consecutively referred to our outpatient clinic for post-COVID pneumonia, undergoing transbronchial biopsy. Several histologic changes were analyzed by computer-assisted morphometric analysis. As organizing pneumonia (OP) was consistently detected, fibrosis and inflammation were also evaluated in transbronchial biopsies from 28 control patients with histologic confirmation of OP. Tissue SARS-CoV-2 and the subgenomic transcripts were investigated. Morphologic findings were correlated with clinical and radiologic data. Results.--Long COVID patients showed lower inflammation than controls (P < .001) despite a similar fibrotic extension. When considering separately the 2 long COVID groups, the same inflammatory infiltrate extension was found, whereas a higher fibrotic remodeling characterized the immunocompetent subgroup (P = .05). Molecular investigation showed that SARS-CoV-2 was present in tissue samples obtained from 3 long COVID patients. Conclusions.--Long COVID patients showed a peculiar OP pattern, with more vascular and fibrotic changes. SARS-CoV-2 RNA, even in replicative status, can be detected in lung biopsies of both immunocompetent and immunocompromised patients. This pilot study is a forerunner of more in-depth lung tissue investigations to gain a better understanding of long COVID pathobiology. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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