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Urease and human glioblastoma (U87) cells growth inhibitory iridoid glycoside acetates from Nyctanthes arbor-tristis Linn.

The present study was undertaken on the chemical constituents of ethanol extract of aerial parts of Nyctanthes arbor-tristis Linn., and their determination of growth inhibitory activity against glioblastoma multiforme cell line (U87) and urease inhibitory activity. Six constituents were isolated inc...

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Published in:Natural Product Research Vol. 39; no. 12; pp. 3486 - 3495
Main Authors: Sana, Talea, Zehra, Sumbul, Khan, Majid, Siddiqui, Bina Shaheen, Simjee, Shabana Usman, Begum, Sabira, Hadda, Taibi B.
Format: Journal Article
Published: Taylor & Francis Ltd Jun2025
Online Access:View this record in EBSCOhost
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      jtl: Natural Product Research
      issn: 14786419
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      dt: Jun2025
      vid: 39
      iid: 12
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      pub: Taylor & Francis Ltd
      place: Philadelphia, Pennsylvania
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        185785284
        176741246
        10.1080/14786419.2024.2340059
        185785284
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        atl: Urease and human glioblastoma (U87) cells growth inhibitory iridoid glycoside acetates from Nyctanthes arbor-tristis Linn.
      aug:
        au:
          Sana, Talea
          Zehra, Sumbul
          Khan, Majid
          Siddiqui, Bina Shaheen
          Simjee, Shabana Usman
          Begum, Sabira
          Hadda, Taibi B.
        affil: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
      sug:
      ab: The present study was undertaken on the chemical constituents of ethanol extract of aerial parts of Nyctanthes arbor-tristis Linn., and their determination of growth inhibitory activity against glioblastoma multiforme cell line (U87) and urease inhibitory activity. Six constituents were isolated including two new arbortristoside F tetraacetate (1) and arbortristoside G heptaacetate (2) and four known arborside A tetraacetate (3), arborside C pentaacetate (4), 6,7-di-O-acetyl-6β-hydroxyloganin hexaacetate (5) and nyctanthoside heptaacetate (6) iridoid glycoside acetates. Their structures were elucidated using spectroscopic methods, including 1D and 2D NMR and mass analyses. Compounds 3 and 6 showed significant growth inhibition of U87 cell line (76.41 and 87.62% inhibition) respectively while 2, 4 and 5 showed moderate inhibition. 3 and 6 showed notable urease inhibition (IC50 = 17.2 ± 0.4 and 17.2 ± 0.7 µM) respectively, and IC50 of 2, 4 and 5 were 23.8 − 56.3 µM. Compound 1 was inactive.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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