Interaction of Genetics and Dietary Patterns Scored by the High Healthy Eating Index in Hyperhomocysteinaemia Influencing Cardiovascular Disease Risk.
Hyperhomocysteinaemia has been associated with increased cardiovascular disease (CVD) risk, but the complex interplay between genetic determinants and modifiable lifestyle factors in modulating homocysteine (HC) levels remains incompletely understood. We aimed to investigate the aetiology of hyperho...
| Publicado en: | Nutrition Bulletin Vol. 50; no. 2; pp. 311 - 326 |
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| Autores principales: | , |
| Formato: | research tables/charts Journal Article |
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Wiley-Blackwell
Jun2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=185816139&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 185816139 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14719827 F0S jtl: Nutrition Bulletin issn: 14719827 maglogo: Y pubinfo: dt: Jun2025 vid: 50 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 185816139 184537467 185816139 185816139 10.1111/nbu.70007 185816139 ppf: 311 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Interaction of Genetics and Dietary Patterns Scored by the High Healthy Eating Index in Hyperhomocysteinaemia Influencing Cardiovascular Disease Risk. aug: au: Park, Sunmin Kang, Suna affil: Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo University, Asan, South Korea sug: subj: Hyperhomocysteinemia Etiology Hyperhomocysteinemia Familial and Genetic Genetics Disease Susceptibility Dietary Patterns Eating Behavior Life Style Metabolic Syndrome X Cardiovascular Risk Factors Risk Assessment South Korea Funding Source Human Male Female Adult Middle Age Cross Sectional Studies Homocysteine Blood Genome Wide Association Study Nutrients Food Intake Multiple Logistic Regression Vitamin B12 Metabolism Folic Acid Metabolism Methionine Metabolism Liver Diseases Inflammation Plant-Based Diet Genetic Risk Score Energy Intake Glycemic Index Smoking Alcohol Drinking Odds Ratio Confidence Intervals Chi Square Test One-Way Analysis of Variance P-Value Data Analysis Software Descriptive Statistics Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Hyperhomocysteinaemia has been associated with increased cardiovascular disease (CVD) risk, but the complex interplay between genetic determinants and modifiable lifestyle factors in modulating homocysteine (HC) levels remains incompletely understood. We aimed to investigate the aetiology of hyperhomocysteinaemia by examining the interactions between genetic predisposition, dietary patterns and other lifestyle factors and their potential associations with metabolic syndrome (MetS) and CVD risk. Cross‐sectional analysis from the Korean Genome and Epidemiology Study, a hospital‐based cohort conducted by the Korean Centers for Disease Control and Prevention from 2012 to 2016. Korean adults (n = 62 743, aged 40–79 years) were categorised into Low‐HC (n = 53 450) and High‐HC (n = 9293) groups based on a 15 μM serum homocysteine cutoff. Demographic, anthropometric and biochemical data were analysed. Genome‐wide association and gene–environment interaction models explored genetic variants influencing hyperhomocysteinaemia and their interplay with lifestyle factors, including nutrient intake. Multivariable logistic regression assessed associations between hyperhomocysteinaemia and metabolic/CVD risks, adjusting for covariates. Genetic variant–environment interaction analyses identified genetic determinants and their interactions with diet/lifestyle. The High‐HC group exhibited an elevated MetS risk. Hyperhomocysteinaemia was correlated with liver damage, inflammation and CVD risks. Low vitamin B12 intake (< 5.4 μg/day) showed a stronger association with hyperhomocysteinaemia than low folate intake (< 350 μg/day), with combined deficiencies exacerbating hyperhomocysteinaemia. An inverse relationship was observed between hyperhomocysteinaemia and healthy eating indices like Asian balanced and plant‐based diets. Variants in MTHFR, NOX4, PLOD1, MIIP, PAX6 and CBS genes, involved in methionine/cysteine metabolism, exhibited differential expression in skeletal muscle, liver and adipose tissues. High polygenic risk scores interacted with poor diet quality, excess energy intake, a high glycemic index, smoking and heavy alcohol consumption to contribute to hyperhomocysteinaemia. In conclusion, these findings elucidate the complex interplay between genetics, diet and lifestyle in modulating homocysteine levels, providing insights for personalised nutrition strategies to mitigate CVD risk. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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