Clinical effect analysis of recanalization treatment for acute ischemic stroke with large infarct core caused by intracranial atherosclerotic stenosis and cardiac embolism.
Objective To investigate the short -term efficacy, long - term outcome and safety of recanalization treatment in patients with acute ischemic stroke presenting with large infarct core caused by intracranial atherosclerotic stenosis (ICAS) versus cardiac embolism (CE). Methods A total of 96 acute isc...
| Publicado en: | Chinese Journal of Contemporary Neurology & Neurosurgery Vol. 25; no. 5; pp. 441 - 447 |
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| Autores principales: | , , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
Chinese Journal of Contemporary Neurology & Neurosurgery
May2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=185856420&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 185856420 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16726731 FDQ6 jtl: Chinese Journal of Contemporary Neurology & Neurosurgery issn: 16726731 maglogo: N pubinfo: dt: May2025 vid: 25 iid: 5 pid: 80951 pub: Chinese Journal of Contemporary Neurology & Neurosurgery artinfo: ui: 185856420 185856420 185856420 10.3969/j.issn.1672-6731.2025.05.013 185856420 ppf: 441 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Clinical effect analysis of recanalization treatment for acute ischemic stroke with large infarct core caused by intracranial atherosclerotic stenosis and cardiac embolism. aug: au: ZHU Jin-zhao XIE Wei-zheng ZHANG Jian-gang FENG Guang affil: Department of Neurology, The People's Hospital of Anyang City, Anyang 455000, He'nan, China sug: subj: Ischemic Stroke Surgery Acute Disease Surgery Thrombectomy Intracranial Arteriosclerosis Complications Constriction, Pathologic Complications Embolism Complications Cardiovascular Diseases Complications Treatment Outcomes Patient Safety Stents Utilization Human China NIH Stroke Scale Scales Intracranial Hemorrhage Hernia Fatal Outcome Clinical Trials Descriptive Statistics Chi Square Test Funding Source ab: Objective To investigate the short -term efficacy, long - term outcome and safety of recanalization treatment in patients with acute ischemic stroke presenting with large infarct core caused by intracranial atherosclerotic stenosis (ICAS) versus cardiac embolism (CE). Methods A total of 96 acute ischemic stroke patients with large infarct core who underwent recanalization treatment at The People's Hospital of Anyang City from January 2022 to January 2023 were enrolled. Based on etiology, patients were divided into ICAS group (n = 52) and CE group (n = 44). Short-term efficacy was assessed using the National Institutes of Health Stroke Scale (NIHSS) at 14 d postoperatively, while long-term outcome was evaluated using the modified Rankin Scale (mRS) at 90 d postoperatively. Safety outcome included rate of symptomatic intracranial hemorrhage (sICH), intracranial hemorrhage, cerebral herniation within 24 h postoperatively, and fatality rate at 90 d postoperatively. Results A statistically significant difference in NIHSS score was observed between the ICAS group and the CE group (F = 5.821, P = 0.023), with the CE group having higher NIHSS score than the ICAS group at admission (t = - 2.324, P = 0.022). Both groups showed significant differences in NIHSS score between admission and 14 d postoperatively (F = 589.322, P = 0.000), with the CE group demonstrating lower NIHSS score at 14 d postoperatively compared to admission (t = 4.173, P = 0.001). The ICAS group exhibited a higher rate of favorable outcome at 90 d postoperatively [44.23% (23/52) vs. 25% (11/44); χ2 = 3.853, P = 0.050]. No significant differences were observed between the 2 groups in sICH, intracranial hemorrhage, cerebral herniation rate, or 90 d fatality rate (P > 0.05, for all). Conclusions Recanalization treatment for acute ischemic stroke patients with large infarct core caused by CE demonstrates more pronounced short-term efficacy, while ICAS presenting with better long- term outcome, and there is no significant difference in safety between the 2 groups. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: Chinese refInfo: holdings: @attributes: islocal: N |
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