Rapid On-Site Evaluation with Pancreatic Fine-Needle Biopsies: Successes and Challenges.
Background: Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) using larger, next-generation cutting needles is a minimally invasive method for the diagnosis of pancreatic lesions. Rapid on-site evaluation (ROSE) is employed to render preliminary diagnoses, ensure specimen adequacy, and triag...
| Publicado en: | Acta Cytologica Vol. 69; no. 3; pp. 291 - 304 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Karger AG
2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=185905817&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 185905817 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00015547 10OE jtl: Acta Cytologica issn: 00015547 maglogo: N pubinfo: dt: 2025 vid: 69 iid: 3 pid: 2485 pub: Karger AG artinfo: ui: 185905817 185905817 185905817 10.1159/000544737 185905817 ppf: 291 ppct: 13 formats: tig: atl: Rapid On-Site Evaluation with Pancreatic Fine-Needle Biopsies: Successes and Challenges. aug: au: Helland, T. Leif Zhang, M. Lisa Pitman, Martha B. Torous, Vanda F. affil: Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA sug: subj: Rapid On-Site Evaluation Pancreatic Neoplasms Diagnosis Pancreatic Neoplasms Pathology Biopsy, Needle Methods Reproducibility of Results Evaluation Human Descriptive Statistics Case Studies Comparative Studies ab: Background: Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) using larger, next-generation cutting needles is a minimally invasive method for the diagnosis of pancreatic lesions. Rapid on-site evaluation (ROSE) is employed to render preliminary diagnoses, ensure specimen adequacy, and triage tissue for ancillary testing and can be performed on FNB cores. Given the difficulty of pancreatic cytology and the novelty of ROSE with these larger cutting needles, this study was performed to evaluate discrepancies between ROSE and the final diagnosis to uncover challenging diagnostic areas. Methods: Final reports from pancreatic FNBs with ROSE between January 2019 and December 2021 were reviewed, and the ROSE and final diagnoses were compared. Cases were categorized into nondiagnostic (ND), negative for malignancy (NEG), atypical, neoplastic (NEO), suspicious for malignancy (SFM), and positive for malignant cells (POS). A major discrepancy was defined as an ND/NEG versus NEO/SFM/POS interpretation. Results: A total of 454 cases were identified. The ROSE versus final diagnosis breakdown was as follows: ND/NEG 18.7% versus 16.3%, atypical 6.4% versus 5.1%, NEO 10.8% versus 11.9%, SFM 4.4% versus 2.0%, and POS 59.7% versus 64.8%. The concordance rate was high at 96.9% with only 14 (3.1%) major discrepancies, which included 6 due to interpretive error, 3 due to sampling error, and 5 due to a combination of both. While the majority of lesions in the cohort were conventional ductal adenocarcinomas (76%), there was an over-representation of non-ductal tumors constituting major discrepancies (6/14; 42.9%). Conclusions: ROSE using pancreatic EUS-FNB is possible and provides an accurate interpretation in most cases. Diagnostic challenges remain with non-ductal tumors. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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