Platelet Indices and RDW to Assess Inflammatory Milieu in Subclinical Hashimoto's Thyroiditis.
Background: Serum thyrotropin levels rise above normal while thyroid hormone levels remain within normal ranges, indicating subclinical hypothyroidism. PLT and MPV levels significantly increase in AITD patients; PLT levels are higher in hypothyroidism and Hashimoto's disease, whereas MPV levels are...
| Publicado en: | Clinical Medicine Insights: Endocrinology & Diabetes Vol. 18; pp. 1 - 9 |
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| Autores principales: | , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
6/13/2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=185940088&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 185940088 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11795514 B3KQ jtl: Clinical Medicine Insights: Endocrinology & Diabetes issn: 11795514 maglogo: Y pubinfo: dt: 6/13/2025 vid: 18 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 185940088 185940088 185940088 10.1177/11795514251349337 185940088 ppf: 1 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Platelet Indices and RDW to Assess Inflammatory Milieu in Subclinical Hashimoto's Thyroiditis. aug: au: Elkholy, Aly Efat, Alaa Shoeib, Sabry Salah, Ahmed Tahoon, Marwa Badr, Hytham Reda affil: Hematology Unit, Internal Medicine Department, Menoufia Faculty of Medicine, Egypt sug: subj: Platelet Count Evaluation Erythrocyte Indices Evaluation Thyroiditis, Autoimmune Blood Biological Markers Blood C-Reactive Protein Blood Inflammation Egypt Human Case Control Studies Mean Platelet Volume Erythrocyte Volume Serum Blood Platelets Adult Middle Age Male Female Descriptive Statistics Antibodies Blood Chi Square Test Academic Medical Centers Outpatients Triiodothyronine Blood Thyroxine Blood Thyrotropin Blood Lipids Blood Early Diagnosis Thyroiditis, Autoimmune Diagnosis Thyroiditis, Autoimmune Prognosis Severity of Illness Thyroiditis, Autoimmune Complications Hypothyroidism Drug Therapy Coronary Arteriosclerosis Prevention and Control Nonexperimental Studies T-Tests Mann-Whitney U Test Data Analysis Software Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: Serum thyrotropin levels rise above normal while thyroid hormone levels remain within normal ranges, indicating subclinical hypothyroidism. PLT and MPV levels significantly increase in AITD patients; PLT levels are higher in hypothyroidism and Hashimoto's disease, whereas MPV levels are higher in hyperthyroidism and Graeve's disease. An increased MPV and other abnormal platelet values lead to a higher incidence of cardiovascular events. The aim was to evaluate RDW and platelet indices in Egyptian patients with subclinical Hashimo's thyroiditis using high-sensitivity CRP Hs-CRP as an indicator of inflammation. Methods: Data for patients (60 patients) with subclinical Hashimoto's thyroiditis who visited the Menoufia University Hospital, Internal Medicine outpatient clinic included. We measured RDW, MPV, PDW, PC, LPCR, (FT3), (FT4), (TSH), lipid profile, Hs-CRP, and Antithyroid antibodies. According to Antithyroid antibodies positivity the 60 patients subdivided into 3 groups 1 (negative for Abs), 2 (positive to 1 Ab), and 3 (positive for both Abs). Results: Among our patients 40 (66.7%) tested positive for anti-thyroglobulin Abs while 36 (60.0%) tested positive for antiperoxidase Abs. RDW, MPV, and LPCR demonstrated positive significant correlations with serum Hs-CRP levels. The study revealed negative significant correlations between TSH levels and PDW and between T4 levels and MPV. Conclusion: Early diagnosis of Hashimoto's thyroiditis can be supported by platelet indices and RDW as diagnostic tools and these markers can also offer prognostic insights into disease severity and complications to help initiate timely treatment for hypothyroidism and prevent atherosclerotic cardiovascular disease. Plain Language Summary: CBC indices and inflammatory milieu in Hashimoto's thyroiditis A frequent autoimmune disease that affects the thyroid gland is called Hashimoto's thyroiditis. Early on, it might not exhibit obvious symptoms; this is referred to as subclinical Hashimoto's thyroiditis. Even in this early stage, though, the body may exhibit certain changes that point to inflammation, which is the body's reaction to injury or stress. In this study, we examined a few basic blood test indicators that may indicate inflammation. Measurements of red blood cells and platelets, which are microscopic cells involved in clotting, are among them. In particular, we looked at platelet indices such mean platelet volume, as well as red cell distribution width RDW, a measure of variation in red blood cell size. An established indicator of inflammation, a blood plasma protein called hs-CRP, was also tested. Sixty patients with subclinical Hashimoto's thyroiditis were studied. According to our findings, greater levels of the inflammatory plasma protein hs-CRP were substantially correlated with RBCs anisocytosis RDW, and platelet indices MPV, and LPCR. This implies that the body may already be experiencing low-grade inflammation even when thyroid hormone levels are only slightly off. These blood indicators have the potential to be helpful for early identification and monitoring because they are simple to measure and already included in standard blood tests. Our findings suggest that people with early thyroid problems might already be at risk for inflammation-related complications, and that these simple markers could help doctors assess that risk. However, the study had some limitations, such as the small number of participants and the lack of a healthy control group. More research on larger populations is needed to confirm our results. In summary, our study highlights the potential value of RDW and platelet indices as early indicators of inflammation in subclinical Hashimoto's thyroiditis. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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