Prescriptions for Antipsychotics: Youth with Intellectual/Developmental Disabilities Compared to Youth without Intellectual/Developmental Disabilities.

Purpose: The purpose of this study was to compare antipsychotic use by youth with intellectual/developmental disabilities to youth without IDD as they transitioned from pediatric to adult health care services. In addition, antipsychotic use was compared between youth with different types of IDD (aut...

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Publicado en:Journal of Autism & Developmental Disorders Vol. 55; no. 7; pp. 2512 - 2522
Autores principales: Marquis, Sandra, Marquis, N. Esmé, Lunsky, Yona, McGrail, Kimberlyn M., Baumbusch, Jennifer
Formato: research tables/charts Journal Article
Publicado: Springer Nature Jul2025
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jul2025
      vid: 55
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s10803-024-06344-z
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        atl: Prescriptions for Antipsychotics: Youth with Intellectual/Developmental Disabilities Compared to Youth without Intellectual/Developmental Disabilities.
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          Marquis, Sandra
          Marquis, N. Esmé
          Lunsky, Yona
          McGrail, Kimberlyn M.
          Baumbusch, Jennifer
        affil: https://ror.org/03rmrcq20 School of Nursing, University of British Columbia, T201-2211, V6T 2B5, Wesbrook Mall, Vancouver, BC, Canada
      sug:
        subj:
          Antipsychotic Agents Therapeutic Use
          Antipsychotic Agents Administration and Dosage
          Drugs, Prescription
          Intellectual Disability In Adolescence
          Developmental Disabilities In Adolescence
          Transitional Care
          Child Health Services
          Health Services In Adulthood
          Human
          Male
          Female
          Adolescence
          Adult
          Insulin Resistance
          Diabetes Mellitus, Type 2
          Logistic Regression
          Odds Ratio
          Metformin Administration and Dosage
          Comparative Studies
          Funding Source
          Adolescent: 13-18 years
          Adult: 19-44 years
          Male
          Female
      ab: Purpose: The purpose of this study was to compare antipsychotic use by youth with intellectual/developmental disabilities to youth without IDD as they transitioned from pediatric to adult health care services. In addition, antipsychotic use was compared between youth with different types of IDD (autism, Fetal Alcohol Syndrome, Down syndrome and 'other'). Methods: Population level administrative health data was used to compare the dispensing of antipsychotics for youth aged 15 to 24 years with and without IDD, between 2010 and 2019. Because antipsychotics are associated with metabolic syndrome and type 2 diabetes, we also examined the dispensing data for metformin. In addition, we examined dispensed antipsychotics between different types of IDD. For both dispensing of antipsychotics and metformin, we used multi-variable logistic regression to derive adjusted odds ratios. Results: There were 20,591 youth with IDD and 1,293,791 youth without IDD. Youth with IDD had significantly higher odds of being dispensed an antipsychotic (7.13 (6.82, 7.44)), even when a diagnosis of a psychotic illness was included in the regression. Higher odds were found in all age groups. Youth with IDD also had significantly higher odds of being dispensed metformin (3.739 (3.323, 4.208)) compared to youth without IDD. Youth with autism, FAS and 'other' types of IDD diagnoses all had higher odds of being dispensed an antipsychotic compared to youth with Down syndrome. Conclusion: Compared to youth without IDD, youth with IDD were more frequently dispensed antipsychotics and metformin. These findings have important implications for the health of youth with IDD.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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