Creatine with guanidinoacetic acid improves prefrontal brain oxygenation before, during, and after a cognitive task: A randomized controlled pilot trial.
Background: Preliminary studies suggest that creatine and guanidinoacetic acid (GAA) may function as moderate vasodilators, enhancing tissue oxygen saturation. However, the potential effects of this combination on brain oxygenation in humans remain unknown. Aim: The primary objective of this randomi...
| Publicado en: | Nutrition & Health Vol. 31; no. 2; pp. 363 - 369 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Jun2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=185986358&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 185986358 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02601060 NTH jtl: Nutrition & Health issn: 02601060 maglogo: Y pubinfo: dt: Jun2025 vid: 31 iid: 2 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 185986358 181048648 185986358 185986358 10.1177/02601060241300236 185986358 ppf: 363 ppct: 6 formats: tig: atl: Creatine with guanidinoacetic acid improves prefrontal brain oxygenation before, during, and after a cognitive task: A randomized controlled pilot trial. aug: au: Zanini, Dragana Todorovic, Nikola Ostojic, Sergej M affil: Applied Bioenergetics Lab, Faculty of Sport and PE, 84981University of Novi Sad, Novi Sad, Serbia sug: subj: Creatine Administration and Dosage Acetic Acid Administration and Dosage Prefrontal Cortex Physiology Oxygenation Evaluation Cerebral Blood Volume Physiology Cognition Task Performance and Analysis Dietary Supplementation Human Randomized Controlled Trials Random Assignment Pilot Studies Young Adult Male Female Crossover Design Oxygen Saturation Hemoglobins Analysis Meditation Mindfulness Recovery Descriptive Statistics Two-Way Analysis of Variance Male Female ab: Background: Preliminary studies suggest that creatine and guanidinoacetic acid (GAA) may function as moderate vasodilators, enhancing tissue oxygen saturation. However, the potential effects of this combination on brain oxygenation in humans remain unknown. Aim: The primary objective of this randomized controlled pilot trial was to assess cerebral blood oxygenation indices following a 7-day administration of a mixture containing creatine and GAA in healthy adults. Methods: Nineteen apparently healthy young adults (mean age 21.2 ± 0.4 years; 9 females) were randomly assigned to receive either a mixture (consisting of 2 g of creatine and 2 g of GAA) or a placebo in a crossover design. Oxygen saturation (SpO2) and hemoglobin index (tHb) in the prefrontal cortex were assessed at rest (REST), during meditation that focused on mindful breathing (MED), during a three-component cognitive task (TASK), and during a post-task recovery (REC) before and after 7 days of supplementation. Results: Two-way ANOVA with repeated measures revealed statistically significant differences (treatment vs. time interaction) between interventions for SpO2 during the REST (F = 5.733, P = 0.028), MED (F = 5.897, P = 0.026), and REC phases (F = 6.715, P = 0.018), indicating that the creatine-GAA mixture was more effective than placebo in enhancing oxygen saturation in the prefrontal brain both before, during, and after a cognitive task. Conclusion: These promising findings are of considerable interest for nutritional neuroscience but require validation through well-designed longitudinal trials with larger sample sizes. The study is registered at ClinicalTrials.gov (NCT06371651). pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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