Annona muricata (Soursop) on Hyperuricemia: an ANCOVA meta-analysis of controlled clinical trials.
Background Annona muricata (soursop) is rich in vitamins and flavonoids that reportedly benefit humans. However, there is a scarcity of clinical studies that confirm these benefits in humans. Phenolic compounds and xanthine oxidase inhibitors reduce serum uric acid (SUA) production, accumulation, an...
| Published in: | Australian Journal of Herbal & Naturopathic Medicine Vol. 37; no. 2; pp. 80 - 89 |
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| Main Authors: | , , , |
| Format: | research systematic review tables/charts Journal Article |
| Published: |
National Herbalists Association of Australia (NHAA)
Jun2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186002331&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186002331 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2209119X LFFF jtl: Australian Journal of Herbal & Naturopathic Medicine issn: 2209119X maglogo: N pubinfo: dt: Jun2025 vid: 37 iid: 2 pid: 12599 pub: National Herbalists Association of Australia (NHAA) artinfo: ui: 186002331 186002331 186002331 10.33235/ajhnm.37.2.80-88 186002331 ppf: 80 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Annona muricata (Soursop) on Hyperuricemia: an ANCOVA meta-analysis of controlled clinical trials. aug: au: Salim, Jonathan Rahardja, Theodorus Samuel Fatmawati, Dede Madeline, Abigail affil: Kalideres General District Hospital, Kalideres, West Jakarta, Indonesia sug: subj: Hyperuricemia Drug Therapy Plants, Medicinal Pharmacodynamics Plant Extracts Pharmacodynamics Phytochemicals Pharmacodynamics Uric Acid Blood Uric Acid Drug Effects Plants, Medicinal Therapeutic Use Plant Extracts Therapeutic Use Phytochemicals Therapeutic Use Drug Efficacy Evaluation Human Systematic Review Meta Analysis Analysis of Covariance Adult Middle Age Aged Aged, 80 and Over Male Female PubMed Cochrane Library Data Analysis Software Checklists Confidence Intervals Regression Spearman's Rank Correlation Coefficient Plant Extracts Administration and Dosage Plant Leaves Analysis Fruit Analysis Flavonoids Ascorbic Acid Glycosides Xanthines Antioxidants Fatty Acids Drug Effects Lipids Drug Effects Body Weight Body Mass Index Adipose Tissue Distribution Phenols Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Background Annona muricata (soursop) is rich in vitamins and flavonoids that reportedly benefit humans. However, there is a scarcity of clinical studies that confirm these benefits in humans. Phenolic compounds and xanthine oxidase inhibitors reduce serum uric acid (SUA) production, accumulation, and renal excretion of SUA. Objectives Exploring the effects of soursop-containing preparations on SUA levels in individuals with hyperuricemia. Methods We analysed controlled clinical trials filtered from PubMed, the New England Journal of Medicine, PubMed Central, Cochrane, and citation searches using specific keywords. We investigated all studies conducted between 2017 and 2023 that included control groups and pre- and post-intervention measurements. The risk of bias was assessed for the non-randomised intervention studies and modified Jadad scores were used to measure the quality of each included study. The mean difference (MD) and heterogeneity were calculated using the Hartung-Knapp-adjusted random effects model for the analysis of covariance in the Recovered Effect Estimates Meta-Analysis using the metafor package in R. Results This novel meta-analysis included 15 studies with 937 participants aged 20-90 years. Most participants consumed preparations containing soursop at least once per week. Soursop significantly reduced SUA (MD: -1.14[-1.82 to -0.45], p=0.0031; I-squared = 98.03%, p<0.0001). However, this reduction was not statistically significant for preparations containing only soursop leaves (MD: -1.15[-2.73 to 0.43], p=0.1130; I-squared=95.81%, p<0.0001). Conclusion Intake of soursop-containing preparations is beneficial for individuals with high uric acid levels, particularly those with limited access, resistance or allergies to uric acid medications. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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