Diarylheptanoid-flavanone adducts from Alpinia officinarum and their neuroprotective activities.
Guided by the characteristic highly π-conjugated system of HPLC-UV experiments, four pairs of enantiomeric diarylheptanoid-flavanone adducts, officinoids A–D (1 – 4), were isolated from the rhizomes of medicinal plant Alpinia officinarum. Their structures with absolute configurations were fully char...
| Publicado en: | Fitoterapia Vol. 184 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Jul2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186132751&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186132751 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0367326X JF4 jtl: Fitoterapia issn: 0367326X maglogo: N pubinfo: dt: Jul2025 vid: 184 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 186132751 186132751 186132751 10.1016/j.fitote.2025.106594 186132751 ppct: 1 formats: tig: atl: Diarylheptanoid-flavanone adducts from Alpinia officinarum and their neuroprotective activities. aug: au: Ren, Teng Miao, Qiuping Pan, Yan Zhang, Shiqing Shi, Lei Wang, Ying Ye, Wen-Cai Wu, Zhen-Long Huang, Xiao-Jun Song, Jian-Guo affil: State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, People's Republic of China sug: subj: Hydrocarbons, Aromatic Analysis Flavanones Analysis Plants, Medicinal Analysis Neuroprotective Agents Analysis Spectrum Analysis X-Rays Methods Chromones Neurons Injuries Oxygenation Glucose Molecular Structure ab: Guided by the characteristic highly π-conjugated system of HPLC-UV experiments, four pairs of enantiomeric diarylheptanoid-flavanone adducts, officinoids A–D (1 – 4), were isolated from the rhizomes of medicinal plant Alpinia officinarum. Their structures with absolute configurations were fully characterized through a combination of extensive spectroscopic analysis, single-crystal X-ray diffraction, and density functional theory quantum chemical calculation. These isolated compounds represent a new class of diarylheptanoid-flavanone adducts with an unprecedented C-11–C-8′(C-6′) and C-9– O –C-7′ connection mode. Notably, compounds 3 and 4 contain an unusual ketal motif in the dihydropyrano[2,3- f ]chromone or dihydropyrano[3,2- g ]chromone skeleton. In the bioactivity assays, compound 2 exhibited significant neuroprotective effects against neuronal injury induced by oxygen-glucose deprivation and re‑oxygenation (OGD/R) in SH-SY5Y cells. [Display omitted] pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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