Systematic Search and Modified e-Delphi Consensus for Serum Bone Biomarkers in Humans and Animal Models with SCI: Methodology.
Alterations to bone metabolism deteriorations in bone density and architecture after spinal cord injury (SCI) are complex and multifactorial: mechanical unloading, impaired osteoblast activity, altered hormone levels, and regional blood flow combine to increase lower extremity fracture incidence and...
| Published in: | Topics in Spinal Cord Injury Rehabilitation Vol. 31; no. 2; pp. 13 - 29 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | research systematic review tables/charts Journal Article |
| Published: |
KnowledgeWorks Global, Ltd
Spring2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186136768&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186136768 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10820744 0OF jtl: Topics in Spinal Cord Injury Rehabilitation issn: 10820744 maglogo: N pubinfo: dt: Spring2025 vid: 31 iid: 2 pid: 81084 pub: KnowledgeWorks Global, Ltd place: Richmond, Virginia artinfo: ui: 186136768 186136768 186136768 10.46292/sci24-00042 186136768 ppf: 13 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Systematic Search and Modified e-Delphi Consensus for Serum Bone Biomarkers in Humans and Animal Models with SCI: Methodology. aug: au: Tsang, Philemon Cleland, Matthew Wiest, Matheus Cowley, Kristine C. Newton, Emily Patsakos, Eleni Ponzano, Matteo Giangregorio, Lora Aliabadi, Saina Armstrong, Katrina Fouad, Karim Magnuson, David Craven, B. Catharine affil: KITE Research Institute, Toronto Rehabilitation Institute - University Health Network, Toronto, ON, Canada sug: subj: Spinal Cord Injuries Rehabilitation Bone and Bones Metabolism Serum Biological Markers Consensus Human Animal Studies Systematic Review Embase Medline Cochrane Library CINAHL Database Delphi Technique Purposive Sample Male Female Multidisciplinary Care Team Male Female ab: Alterations to bone metabolism deteriorations in bone density and architecture after spinal cord injury (SCI) are complex and multifactorial: mechanical unloading, impaired osteoblast activity, altered hormone levels, and regional blood flow combine to increase lower extremity fracture incidence and mortality. Bone biomarkers are vital to detect disease, identify candidate therapies, monitor therapy effectiveness, and quantify fracture risk. This study aimed to synthesize available literature on serum and plasma bone biomarkers in both animal and human SCI models and to generate consensus regarding their appropriateness for use across the translational continuum. A systematic search was conducted; 4731 studies were excluded, yielding 125 studies for data extraction. Data were reviewed by an interdisciplinary panel of experts. Through a modified e-Delphi process, consensus statements were iteratively developed regarding the appropriateness of 14 serum bone biomarkers in human and animal models and across the translational continuum. The consensus process highlighted challenges in interpreting animal and human models, emphasizing the need for methodological rigor and standardized biomarker reporting. Consideration of diurnal variations in biomarkers and model selection (transection vs. clip) underscored the complexity of SCI research. Limitations included defining "adult" rodents and lack of data on sex-related differences in biomarkers and their interpretation, given most human data were obtained from males and animal data from females. The consensus statements provide guidance, address gaps in reporting and interpretation of biomarkers, promote use of standardized protocols and assay kits, and emphasize interdisciplinary approaches to advancing scientific discovery and facilitating knowledge translation. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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