Peripheral Vascular Dysfunction Following Spinal Cord Injury: A Systematic Review and Meta-Analysis.
Spinal cord injury (SCI) has been shown to impact vascular function and increase the risk of cardiovascular disease (CVD). However, data are limited regarding prognostic factors for identifying subclinical CVD risk in individuals with SCI. To identify maladaptive structural and functional changes to...
| Publicado en: | Topics in Spinal Cord Injury Rehabilitation Vol. 31; no. 2; pp. 88 - 104 |
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| Autores principales: | , , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
KnowledgeWorks Global, Ltd
Spring2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186136774&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186136774 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10820744 0OF jtl: Topics in Spinal Cord Injury Rehabilitation issn: 10820744 maglogo: N pubinfo: dt: Spring2025 vid: 31 iid: 2 pid: 81084 pub: KnowledgeWorks Global, Ltd place: Richmond, Virginia artinfo: ui: 186136774 186136774 186136774 10.46292/sci24-00036 186136774 ppf: 88 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Peripheral Vascular Dysfunction Following Spinal Cord Injury: A Systematic Review and Meta-Analysis. aug: au: Thordarson, Thomas Miller, Tiev Calderón-Juárez, Martín Hosseinzadeh, Ali Malik, Raza Sachdeva, Rahul Krassioukov, Andrei V. affil: International Collaboration on Repair Discoveries, Faculty of Medicine, University of British Columbia, Vancouver, Canada sug: subj: Spinal Cord Injuries Complications Peripheral Vascular Diseases Risk Factors Cardiovascular Risk Factors Risk Assessment Human Systematic Review Meta Analysis Medline CINAHL Database Embase Checklists Severity of Injury Spinal Cord Injuries Therapy Treatment Outcomes Arteries Anatomy and Histology Endothelium Physiology Blood Circulation Lipoproteins, HDL Cholesterol Blood Carotid Intima-Media Thickness Arterial Stiffness Shear Blood Glucose Triglycerides Blood Cardiovascular System Physiology Descriptive Statistics Data Analysis Software ab: Spinal cord injury (SCI) has been shown to impact vascular function and increase the risk of cardiovascular disease (CVD). However, data are limited regarding prognostic factors for identifying subclinical CVD risk in individuals with SCI. To identify maladaptive structural and functional changes to central and peripheral vasculature resulting from SCI and to assess the effect of SCI on these parameters relative to able-bodied comparators. This review was prospectively registered. A systematic search was performed using PRISMA guidelines. Bias was assessed using the ROBINS-I and AHRQ tools. Studies reporting structural or functional changes to vasculature following SCI were included. Data on participant and injury characteristics, outcomes, and assessments used were extracted. Meta-analyses were conducted for adequately powered subgroups based on outcome type, measurement site, and level of injury. A total of 49 studies involving 1026 individuals with SCI and 941 able-bodied comparators were included. Most studies described injury level and severity using standardized impairment classifications. Subgroup analyses showed significantly reduced arterial diameter, compliance, endothelial function, blood flow volume, and high-density lipoprotein (HDL) cholesterol concentration among people with SCI compared to controls. Intima-media thickness, arterial stiffness, shear rate, and blood glucose and triglyceride concentrations were significantly greater for people with SCI compared to controls. Additional subgroup analyses were underpowered. This review synthesizes the current literature reporting central and peripheral vasculature outcomes in people with SCI and able-bodied controls. Between-group differences were observed for several structural and functional vascular outcomes, which suggests that SCI has a significant impact on multiple subclinical CVD risk factors. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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