Altered Metabolic Activity and Morphology of Lower Limb Muscles 1–2 Years Following Anterior Cruciate Ligament Reconstruction.

The purpose of this study was to explore between‐limb differences in gluteal, quadriceps, hamstring, and triceps surae muscle size and activity during a repeated vertical jump‐landing task in individuals with a history of unilateral anterior cruciate ligament reconstruction (ACLR). Twelve recreation...

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Published in:Scandinavian Journal of Medicine & Science in Sports (John Wiley & Sons, Inc.) Vol. 35; no. 6; pp. 1 - 11
Main Authors: Dutaillis, Benjamin, Collings, Tyler, Bellinger, Philip, Timmins, Ryan G., Kennedy, Benjamin, Bourne, Matthew N.
Format: diagnostic images equations & formulas pictorial research tables/charts Journal Article
Published: John Wiley & Sons, Inc. Jun2025
Online Access:View this record in EBSCOhost
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      jtl: Scandinavian Journal of Medicine & Science in Sports (John Wiley & Sons, Inc.)
      issn: 16000838
      maglogo: N
    pubinfo:
      dt: Jun2025
      vid: 35
      iid: 6
      pid: 52269
      pub: John Wiley & Sons, Inc.
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        186137956
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        10.1111/sms.70079
        186137956
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        atl: Altered Metabolic Activity and Morphology of Lower Limb Muscles 1–2 Years Following Anterior Cruciate Ligament Reconstruction.
      aug:
        au:
          Dutaillis, Benjamin
          Collings, Tyler
          Bellinger, Philip
          Timmins, Ryan G.
          Kennedy, Benjamin
          Bourne, Matthew N.
        affil: School of Health Sciences and Social Work, Griffith University, Gold Coast Campus, Gold Coast, Australia
      sug:
        subj:
          Anterior Cruciate Ligament Reconstruction Adverse Effects
          Jumping
          Task Performance and Analysis
          Lower Extremity
          Muscle, Skeletal Physiology
          Muscle, Skeletal Anatomy and Histology
          Human
          Cross Sectional Studies
          Descriptive Statistics
          Data Analysis Software
          Magnetic Resonance Imaging
          Univariate Statistics
          Confidence Intervals
          Linear Regression
          Male
          Female
          Adult
          Adult: 19-44 years
          Male
          Female
      ab: The purpose of this study was to explore between‐limb differences in gluteal, quadriceps, hamstring, and triceps surae muscle size and activity during a repeated vertical jump‐landing task in individuals with a history of unilateral anterior cruciate ligament reconstruction (ACLR). Twelve recreationally active participants with a unilateral history of ACLR involving a semitendinosus autograft (1–2.5 years post‐surgery) underwent functional magnetic resonance imaging (fMRI) before and immediately after 60 vertical jumps. Exercise‐induced increases in transverse (T2) relaxation times and resting muscle volumes were measured in 12 lower limb muscles. Linear mixed models were used to explore differences between the ACLR and uninjured contralateral limb, as well as their relationship with vertical jump performance. Reconstructed limbs displayed smaller muscle volumes in vastus medialis (p = 0.028), rectus femoris (p = 0.019), semitendinosus (p < 0.001), and gastrocnemius lateral head (p = 0.028) than homonymous muscles in the uninjured contralateral limb. Limbs with a history of ACLR also exhibited smaller percentage changes in T2 relaxation time for semitendinosus (p < 0.001), semimembranosus (p = 0.002), lateral gastrocnemius (p = 0.014), and soleus (p = 0.008), while the vastus lateralis displayed a greater increase (p = 0.001) than uninjured contralateral limbs. Between‐limb asymmetry in quadriceps muscle volume and activity was associated with between‐limb asymmetry in vertical jump‐landing impulse (r2 = 0.30–0.34). The findings from this study may help to inform the design of exercise interventions aimed at restoring lower limb function and reducing reinjury risk in individuals with a history of ACLR.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        equations & formulas
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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