Neuroanatomical basis of language ability in an autism subgroup with moderate language deficits.
Children with autism spectrum disorder (ASD) are highly heterogenous in their language abilities. A number of studies have shown neural correlates of language deficits in children with ASD, but the underlying neuroanatomical foundation of early language deficits in ASD remains largely elusive. In th...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 34; no. 6; pp. 1895 - 1905 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2025
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186157334&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186157334 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Jun2025 vid: 34 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 186157334 180723706 186157334 186157334 10.1007/s00787-024-02605-5 186157334 ppf: 1895 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Neuroanatomical basis of language ability in an autism subgroup with moderate language deficits. aug: au: Xiao, Yaqiong Zhang, Ningxuan Huang, Kaiyu Zhang, Shuiqun Xin, Jin Huang, Qingshan Yi, Aiwen affil: https://ror.org/03hz5th67 Faculty of Life and Health Sciences, Shenzhen University of Advanced Technology, 518107, Shenzhen, China sug: subj: Autism Spectrum Disorder Complications Autism Spectrum Disorder Radiography Child Development Magnetic Resonance Imaging Methods Auditory Perceptual Disorders Pathology Language Disorders Pathology Brain Pathology Human Funding Source Male Female Infant Child, Preschool Child China Chinese Persons White Matter Radiography White Matter Pathology Gray Matter Radiography Gray Matter Pathology Temporal Lobe Physiopathology Parietal Lobe Physiopathology Hippocampus Language Descriptive Statistics Infant: 1-23 months Child, Preschool: 2-5 years Child: 6-12 years Male Female ab: Children with autism spectrum disorder (ASD) are highly heterogenous in their language abilities. A number of studies have shown neural correlates of language deficits in children with ASD, but the underlying neuroanatomical foundation of early language deficits in ASD remains largely elusive. In this study, we analyzed MRI data from a cohort of Chinese children with ASD (n = 67) and typical development (TD, n = 37) aged 1.5 to 6.5 years. The ASD sample was classified into two subgroups based on the median of the language scores: ASD with moderate language deficits (ASDmoderate, n = 34) and ASD with severe language deficits (ASDsevere, n = 34). We tested the group differences in the brain volumes between TD and two ASD subgroups, and also examined the associations between cortical grey matter volume and language abilities in TD and ASD subgroups, separately. We observed significant group differences in grey matter and white matter volume, with post-hoc analyses specifically indicating significant differences between TD and ASDmoderate subgroup. Significant correlations between grey matter volume and language scores were observed exclusively within the ASDmoderate subgroup, including positive associations in the bilateral superior temporal gyrus, hippocampus, and left inferior parietal lobe, and negative correlations in the bilateral precuneus. These findings provide novel evidence for the neuroanatomical basis related to language ability in an ASD subgroup with moderate language deficits, and offer new insights into the heterogeneity of language deficits in children with ASD. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|