Electrophysiological indices of reward anticipation as ADHD risk and prognostic biomarkers.
The attention-deficit/hyperactivity disorder (ADHD) clinical phenotype has limitations for deciphering ADHD etiology and predicting prognosis. Although relative to the clinical phenotype, intermediate phenotypes may have better explanatory and prognostic power, the extent to which ADHD intermediate...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 34; no. 6; pp. 1905 - 1917 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186157335&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186157335 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Jun2025 vid: 34 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 186157335 180723561 186157335 186157335 10.1007/s00787-024-02606-4 186157335 ppf: 1905 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Electrophysiological indices of reward anticipation as ADHD risk and prognostic biomarkers. aug: au: Bunford, Nóra Ágrez, Kristóf Hámori, György Koller, Júlia Pulay, Attila Nemoda, Zsófia Réthelyi, János M. affil: https://ror.org/03zwxja46 Clinical and Developmental Neuropsychology Research Group, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary sug: subj: Attention Deficit Hyperactivity Disorder Risk Factors Attention Deficit Hyperactivity Disorder Prognosis Biological Markers Evoked Potentials Electrophysiology Reward Risk Assessment Human Male Female Adolescence Prospective Studies Comparative Studies Descriptive Statistics Age Factors Sex Factors Depression Alcohol Drinking Prediction Models Electroencephalography Brain Mapping Factor Analysis Analytic Research Psychomotor Performance Adolescent Behavior Funding Source Adolescent: 13-18 years Male Female ab: The attention-deficit/hyperactivity disorder (ADHD) clinical phenotype has limitations for deciphering ADHD etiology and predicting prognosis. Although relative to the clinical phenotype, intermediate phenotypes may have better explanatory and prognostic power, the extent to which ADHD intermediate phenotypes are associated with ADHD risk and prognosis is unknown. The aim of this study was to evaluate evidence for event-related potential (ERP) measures of reward anticipation as ADHD risk and prognostic biomarkers. We examined, whether (1) in a sample of adolescents (N = 304; Mage = 15.78 years, SD = 1.08; 39.5% female), accounting for the effects of age, sex, ADHD severity and depression, ERPs are associated with ADHD polygenic risk scores (PRSs) (ADHD risk) and (2) in a sample of adolescents at-risk for ADHD (n = 99; Mage = 15.78 years, SD = 1.08; 39.5% female), accounting for the effects of age, sex, ADHD severity, depression, and baseline outcome values, ERPs are associated, prospectively, with alcohol misuse (ADHD prognosis). In adolescents, greater ADHD PRSs were associated with lower electrophysiological anticipatory attention to motivationally relevant feedback (b = −0.115, p =.046 95%CI [−0.228; −0.002]). The predictors accounted for 5% of the variance in the outcome. In adolescents at-risk for ADHD, at 18-month follow-up, lower electrophysiological anticipatory attention to motivationally relevant feedback was associated with greater alcohol consumption (b = −7.454, p =.007, 95%CI [−12.873; −2.034]). The predictors accounted for 31% of the variance in this outcome. These findings were replicated in sensitivity analyses with behavioral performance variables added as covariates. The current findings support the hypothesis that ERP amplitudes of reward anticipation may be ADHD risk and prognostic biomarkers and suggest that intermediate phenotypes may confer advantages over the ADHD clinical phenotype in delineating etiology and predicting prognosis. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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