Impact of malodour on health‐related quality of life of patients with chronic wounds due to volatile organic compounds.
Chronic wounds significantly impact health‐related quality of life (HRQoL). Unpleasant wound odour, caused by bacterial colonisation and necrotic processes, is a distressing symptom. Its exact composition is not well understood, but it could be the basis for a personalised odour avoidance strategy....
| Publicado en: | Wound Repair & Regeneration Vol. 33; no. 3; pp. 1 - 13 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
May/Jun2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186162973&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186162973 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: May/Jun2025 vid: 33 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 186162973 186162973 186162973 10.1111/wrr.70033 186162973 ppf: 1 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Impact of malodour on health‐related quality of life of patients with chronic wounds due to volatile organic compounds. aug: au: Stuermer, E. K. Nathrath, C. Lober, H. Wigger, M. Janke, T. M. Augustin, M. Dittmer, M. Sielemann, S. Liegenfeld, S. C. affil: Department of Vascular Medicine, Translational Wound Research, University Medical Center Hamburg‐Eppendorf (UKE), Hamburg, Germany sug: subj: Odors Wounds and Injuries Risk Factors Chronic Disease Quality of Life Environmental Exposure Risk Assessment Human Middle Age Aged Pilot Studies Gas Chromatography-Mass Spectrometry Correlational Studies Staphylococcus Aureus Pseudomonas Infections Enterobacteriaceae Biological Markers Escherichia Coli Ketones Alcohols Necrosis Exploratory Research Questionnaires Middle Aged: 45-64 years Aged: 65+ years ab: Chronic wounds significantly impact health‐related quality of life (HRQoL). Unpleasant wound odour, caused by bacterial colonisation and necrotic processes, is a distressing symptom. Its exact composition is not well understood, but it could be the basis for a personalised odour avoidance strategy. Therefore, this feasibility study explored 92 wounds from 66 patients with the focus on wound odour, bacterial burden and their impact on health related‐quality of life (HRQoL). Volatile organic compounds (VOCs) responsible for wound odours were detected at the molecular level, using gas chromatography–mass spectrometry and ‐ion mobility spectrometry and correlated to the HRQoL. In patients analysed (average age 69 ± 13 years, wound persistence 24.31 ± 70.8 months) 135 pathogens were identified by swabbing including 19% Staphylococcus aureus, 15% Pseudomonas aeruginosa and 35% Enterobacteria. The specific questionnaire 'Wound‐QoL‐14' showed a non‐significant difference in HRQoL in patients with wound odour (2.1 ± 1.0 vs. 1.8 ± 1.0). The latter also had the highest number of VOC detections. The most frequently detected, relevant VOCs from prokaryotic sources were dimethyl‐disulphide and diacetyl‐(2,3‐butanedione). Furthermore, potential biomarkers for specific pathogens were identified, including dimethyl‐trisulphide for P. aeruginosa and indole for Escherichia coli. The most prevalent substance groups were ketones and alcohols. In conclusion, the malodour of chronic wounds is caused by a mixture of the intrinsic odour of bacterial products and necrosis. This exploratory study, which combines the analysis of decoded VOCs and the olfactory assessment of odour, could be a novel, targeted approach for identifying potential 'anti‐wound odour therapies' that will significantly benefit the HRQoL of patients with malodourous tumour wounds, in particular. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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