Effects of Nano-Quercetin on Cypermethrin Induced Liver Injury in Rabbits.
Cypermethrin is a synthetic pyrethroid reported to cause hepatic toxicity and other fatalities in humans as well as animals/birds. Quercetin is a flavonoid that has beneficial health-protective effects, its use is limited because of its poor bioavailability, metabolism through colonic microbial flor...
| Published in: | Journal of Dietary Supplements Vol. 22; no. 4; pp. 571 - 584 |
|---|---|
| Main Authors: | , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Taylor & Francis Ltd
2025
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186248805&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186248805 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19390211 2Y62 jtl: Journal of Dietary Supplements issn: 19390211 maglogo: N pubinfo: dt: 2025 vid: 22 iid: 4 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 186248805 185297829 186248805 186248805 10.1080/19390211.2025.2507612 186248805 ppf: 571 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Effects of Nano-Quercetin on Cypermethrin Induced Liver Injury in Rabbits. aug: au: Ashraf, Maham Akhtar, Bushra Chou, Chi-Chung Saeed, Muhammad Muhammad, Faqir affil: Institute of Physiology and Pharmacology, University of Faisalabad, Faisalabad, Pakistan sug: subj: Quercetin Administration and Dosage Quercetin Therapeutic Use Quercetin Pharmacodynamics Nanoparticles Insecticides Adverse Effects Liver Drug Effects Liver Diseases Drug Therapy Polysaccharides Analysis Hepatotoxicity Prevention and Control Drug Efficacy Evaluation Animal Studies Rabbits Models, Biological Particle Size Drug Toxicity Flavonoids Therapeutic Use Biological Availability Gut Microbiota Metabolism Liver Metabolism Drug Delivery Systems Solvents Drug Stability Dose-Response Relationship, Drug Descriptive Statistics Data Analysis Software ab: Cypermethrin is a synthetic pyrethroid reported to cause hepatic toxicity and other fatalities in humans as well as animals/birds. Quercetin is a flavonoid that has beneficial health-protective effects, its use is limited because of its poor bioavailability, metabolism through colonic microbial flora, and first-pass hepatic metabolism. To overcome these limitations, quercetin was loaded into chitosan nanoparticles by following the solvent evaporation method. The study objectives were synthesizing, characterizing quercetin-loaded chitosan nanoparticles, and determination of hepatoprotective potential against chemical (pyrethroid) induced liver injury in animal models. The nanoparticles were characterized by zeta size and potential, polydispersity index (PDI), entrapment efficiency, and FTIR. The prepared nano-formulation was physically stable and fell within the nanoscale range (188.5 nm) with high entrapment efficiency (80.4%). The study was conducted with four treatment groups (n = 5) comprising 20 rabbits, in which group 1 was the negative control (normal diet), group 2 was a positive control (cypermethrin 24 mg/Kg), group 3 and 4 were treated with low-dose (10 mg/kg) and high-dose (20 mg/kg) quercetin-loaded chitosan nanoparticles respectively, along with cypermethrin 24 mg/kg) for 28 days. It was found that cypermethrin-treated animals have high levels of LFT and histopathological lesions in the liver. Co-administration of quercetin-loaded chitosan nanoparticles with cypermethrin successfully ameliorated hepatotoxicity in rabbits in a dose-dependent manner. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|