Alginate Oligosaccharide and Gut Microbiota: Exploring the Key to Health.
Alginate oligosaccharide (AOS), a degradation product of alginate derived from marine brown algae, has attracted significant attention due to its potent ability to modulate gut microbiota and enhance human health. This review aims to systematically introduce current evidence on the interactions betw...
| Publicado en: | Nutrients Vol. 17; no. 12; pp. 1977 - 2004 |
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| Autores principales: | , , , , , , , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
MDPI
Jun2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186261311&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186261311 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726643 B0TT jtl: Nutrients issn: 20726643 maglogo: N pubinfo: dt: Jun2025 vid: 17 iid: 12 pid: 97109 pub: MDPI artinfo: ui: 186261311 186261311 186261311 10.3390/nu17121977 186261311 ppf: 1977 ppct: 27 formats: tig: atl: Alginate Oligosaccharide and Gut Microbiota: Exploring the Key to Health. aug: au: Song, Meiling Chen, Lin Dong, Chen Tang, Minghui Wei, Yuan Lv, Depeng Li, Quancai Chen, Zhen affil: School of Pharmacy, Jiangsu University, Zhenjiang 212013, China sug: subj: Alginates Analysis Alginates Pharmacodynamics Oligosaccharides Analysis Oligosaccharides Pharmacodynamics Gut Microbiota Drug Effects Molecular Structure Probiotics Fatty Acids, Volatile Intestinal Barrier Function Antioxidants Pharmacodynamics Immune System Inflammation Prevention and Control Infection Prevention and Control Metabolism Drug Effects Uric Acid Drug Effects Antineoplastic Agents Pharmacodynamics Skin Aging Drug Effects ab: Alginate oligosaccharide (AOS), a degradation product of alginate derived from marine brown algae, has attracted significant attention due to its potent ability to modulate gut microbiota and enhance human health. This review aims to systematically introduce current evidence on the interactions between AOS and gut microbial communities, focusing on how AOS improves health through regulating gut microbiota. Initially, the structural factors of AOS that influence their functions are highlighted, including molecular weight, monomer composition, terminal structure, and chemical modifications. Importantly, AOS primarily exerts beneficial effects by adjusting gut microbiota community and outputs, which include the promotion of probiotics, the inhibition of pathogens, the balance of microbiota composition, and the increase of short-chain fatty acid production. Moreover, the discovered mechanisms underlying AOS-mediated health promotion via microbiota modulation are detailed comprehensively, specifically emphasizing intestinal barrier maintenance, antioxidation, dual-regulation of immune and inflammatory responses, pathogenic infection inhibition, metabolic improvement, uric acid excretion promotion, anti-tumor effects, and anti-skin aging. Such beneficial effects make AOS valuable in keeping healthy, preventing disorders, and intervening in diseases. Despite these findings and research progress, there are yet limitations in studying AOS–gut microbiota interactions, such as precise microbiota-targeted structural optimization, personalized nutritional interventions based on microbial characteristics, and broadening the horizon of microbiota-derived metabolic metabolomic profiles. In conclusion, advancing our understanding of the gut microbiota-centered mechanisms of AOS would probably facilitate novel nutritional strategy development for health promotion. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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