Modulation of Gut Microbiota by Whole Encapsulated Brown Seaweed (Himanthalia elongata) in Overweight Subjects: A Randomized Double-Blind Placebo-Controlled Trial.
Background/Objectives: Brown seaweeds, such as Himanthalia elongata, are a promising source of dietary fiber. However, in vivo evidence regarding the effects of H. elongata intake on the human gut microbiota remains limited. This study aimed to evaluate the impact of daily H. elongata consumption on...
| Publicado en: | Nutrients Vol. 17; no. 12; pp. 2047 - 2066 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
MDPI
Jun2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186261381&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186261381 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726643 B0TT jtl: Nutrients issn: 20726643 maglogo: N pubinfo: dt: Jun2025 vid: 17 iid: 12 pid: 97109 pub: MDPI artinfo: ui: 186261381 186261381 186261381 10.3390/nu17122047 186261381 ppf: 2047 ppct: 19 formats: tig: atl: Modulation of Gut Microbiota by Whole Encapsulated Brown Seaweed (Himanthalia elongata) in Overweight Subjects: A Randomized Double-Blind Placebo-Controlled Trial. aug: au: Lopez-Santamarina, Aroa Cardelle-Cobas, Alejandra Mondragon, Alicia del Carmen Cepeda, Alberto Rodriguez, Jose A. Miranda, Jose Manuel affil: Department of Analytical Chemistry, Nutrition and Food Science, School of Veterinary Sciences, University of Santiago de Compostela, 27002 Lugo, Spain sug: subj: Obesity In Adulthood Seaweed Plant Extracts Analysis Food Intake Evaluation Fatty Acids, Volatile Analysis Gut Microbiota Drug Effects Body Composition Drug Efficacy Evaluation Human Adult Middle Age Aged Male Female Randomized Controlled Trials Double-Blind Studies Feces Specimen Handling Pretest-Posttest Control Group Design RNA Sequence Analysis Nutritional Assessment Macronutrients Fatty Acids, Saturated Dietary Proteins Dietary Fiber Descriptive Statistics Body Mass Index Bacteroides Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background/Objectives: Brown seaweeds, such as Himanthalia elongata, are a promising source of dietary fiber. However, in vivo evidence regarding the effects of H. elongata intake on the human gut microbiota remains limited. This study aimed to evaluate the impact of daily H. elongata consumption on the gut microbiota composition and short-chain fatty acid production in overweight adults. Methods: A randomized, double-blind, placebo-controlled trial was conducted in which 10 overweight adult participants consumed 2 g/day of whole H. elongata for 30 days. Fecal samples were collected before and after the intervention for 16S rRNA sequencing and short-chain fatty acid analysis. Dietary intake was evaluated using a 24 h recall and a 3-day dietary record. Nutritional assessment was performed to determine habitual macronutrient consumption. Results: Baseline dietary analysis revealed an imbalanced macronutrient profile characterized by high intakes of total and saturated fats and protein, along with low carbohydrate and fiber consumption. In addition, 50% of the participants were obese, and 50% were overweight based on the BMI. Notable changes in the gut microbiota composition were observed after the intervention, including increases in short-chain fatty acid-producing species, such as Parabacteroides distasonis, Bacteroides eggerthii, Bacteroides uniformis, and Bacteroides obeum. Conclusions: This study provides the first clinical evidence in humans that whole H. elongata can beneficially modulate the gut microbiota composition. These results support the potential use of this seaweed as a functional prebiotic ingredient in dietary strategies aimed at enhancing gut health. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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