Optimized fiducial marker placement using B‐spline surface modeling and graph theory for Cyberknife stereotactic body radiotherapy for superficial tumors.
CyberKnife, an established noninvasive stereotactic radiotherapy technology, has been extensively utilized to treat various malignancies because of its high precision and conformal dose delivery. The success of CyberKnife treatment is crucially dependent on optimal fiducial marker placement. This st...
| Publicado en: | Precision Radiation Oncology Vol. 9; no. 2; pp. 87 - 96 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jun2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186282813&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186282813 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23987324 L3KI jtl: Precision Radiation Oncology issn: 23987324 maglogo: N pubinfo: dt: Jun2025 vid: 9 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 186282813 186034308 186282813 186282813 10.1002/pro6.70017 186282813 ppf: 87 ppct: 9 formats: tig: atl: Optimized fiducial marker placement using B‐spline surface modeling and graph theory for Cyberknife stereotactic body radiotherapy for superficial tumors. aug: au: Huang, Jing Xiong, Xianlong Chen, Cheng Li, Yuhan Wang, Ruijie Dai, Zhitao affil: School of Computer Science and Artificial Intelligence, Wuhan University of Technology, Wuhan, China sug: subj: Radiation Equipment and Supplies Models, Statistical Algorithms Utilization Radiotherapy, Computer-Assisted Methods Neoplasms Radiotherapy Human Male Female Adolescence Adult Middle Age Aged Aged, 80 and Over Funding Source Noninvasive Procedures Dose-Response Relationship, Radiation Radiotherapy, Conformal Methods Retrospective Design Record Review Tumor Markers, Biological Radiographic Image Enhancement Tomography, X-Ray Computed Sensitivity and Specificity Patient Safety Workflow Magnetic Resonance Imaging Data Analysis, Computer Assisted Computer Simulation Time Factors Mathematics Physician Attitudes Descriptive Statistics Data Analysis Software Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: CyberKnife, an established noninvasive stereotactic radiotherapy technology, has been extensively utilized to treat various malignancies because of its high precision and conformal dose delivery. The success of CyberKnife treatment is crucially dependent on optimal fiducial marker placement. This study introduces a novel fiducial marker placement planning algorithm tailored for superficial tumors, which are located 20–50 mm beneath the epidermis. A retrospective analysis was performed on the data collected from three patients with thymus, breast, and submandibular gland tumors. This algorithm generated potential implantation sites by constructing and optimizing a B‐spline surface around the tumor. Candidate points were filtered using multi‐criteria constraints: (1) a minimum of 18‐mm inter‐marker distance, (2) angular separation >30°, and (3) nonoverlapping visibility in 45° oblique digital reconstructed radiographs. To enhance the computational efficiency, a kd‐tree spatial indexing structure was integrated with graph theory, specifically the Bron–Kerbosch algorithm for maximal clique detection. The proposed method achieved a time complexity of O(mlogm+m2+3n3)${\mathrm{O}}({{\mathrm{mlogm}} + {{\mathrm{m}}^2} + {3^{\frac{{\mathrm{n}}}{3}}}})$, demonstrating a significant improvement over the brute‐force O(n3)${\mathrm{O}}({{{\mathrm{n}}^3}})$ approach. The experimental results showed that our algorithm could efficiently plan fiducial marker placement, thereby simplifying the planning process and providing valuable technical support for CyberKnife treatments. pubtype: Academic Journal doctype: diagnostic images equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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