Impact of sociodemographic determinants on enrollment into contemporary lymphoma clinical trials: a systematic review.
While the incidence and survival associated with lymphoma have improved in recent years, outcome disparities related to sociodemographic factors such as age, sex, race, ethnicity, socioeconomic status (SES), and other social determinants of health (SDOH) remain prevalent in the modern era. Clinical...
| Publicado en: | Oncologist Vol. 30; no. 6; pp. 1 - 11 |
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| Autores principales: | , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Jun2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186317272&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186317272 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10837159 IJ7 jtl: Oncologist issn: 10837159 maglogo: N pubinfo: dt: Jun2025 vid: 30 iid: 6 pid: 622 pub: Oxford University Press / USA artinfo: ui: 186317272 186317272 186317272 10.1093/oncolo/oyaf180 186317272 ppf: 1 ppct: 10 formats: tig: atl: Impact of sociodemographic determinants on enrollment into contemporary lymphoma clinical trials: a systematic review. aug: au: Jiang, Jun Yang Li, Ang Romero, Alexis Flowers, Christopher R Nze, Chijioke affil: Section of Hematology & Oncology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA sug: subj: Sociodemographic Factors Social Determinants of Health Research Subject Recruitment Lymphoma Therapy Clinical Trials United States United States Human Systematic Review African Americans Hispanic Americans Adolescence Young Adult Economic Status Aged HIV-Positive Persons Cancer Patients Housing Educational Status Employment Status Race Factors Sex Factors Age Factors Geographic Factors Eligibility Determination Checklists Adolescent: 13-18 years Aged: 65+ years ab: While the incidence and survival associated with lymphoma have improved in recent years, outcome disparities related to sociodemographic factors such as age, sex, race, ethnicity, socioeconomic status (SES), and other social determinants of health (SDOH) remain prevalent in the modern era. Clinical trials are crucial for further improving outcomes, yet not all sociodemographic groups are equally represented in contemporary lymphoma trials. We conducted a systematic review of the literature evaluating the impact of SDOH on enrollment into clinical trials in the United States and identified 21 relevant studies. We confirmed that Black and Hispanic individuals are underrepresented in lymphoma clinical trials, due largely to the geographic distribution of clinical trial sites and exacerbated by globalization of cancer trials. Women may also be less appropriately represented than men, although this association is less robust and consistent. Adolescents and young adults with lymphoma who are older, treated at adult cancer centers, or managed by adult hematologists/oncologists are all less likely to be part of trials. Older adults are also excluded from most lymphoma clinical trials. There is a dearth of data on how other SDOHs including education, employment, and household income contribute to differences in clinical trial enrollment. Further research is required to explore the intersection of demographics, SES, insurance status, and enrollment into lymphoma clinical trials. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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