Bifidobacterium longum subsp infantis (EVC001) is associated with reduced incidence of necrotizing enterocolitis stage ≥2 and bloody stools in premature babies.
Objective: To utilize an evidence-based probiotic protocol to achieve a 50% reduction in necrotizing enterocolitis (NEC) ≥ stage 2 and bloody stools. Study design: From January 2022 through September 2023, daily enteral Bifidobacterium longum ssp. infantis EVC001 (B. infantis EVC001) was administere...
| Publicado en: | Journal of Perinatology Vol. 45; no. 5; pp. 635 - 642 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
May2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186336180&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186336180 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07438346 DZF jtl: Journal of Perinatology issn: 07438346 maglogo: Y pubinfo: dt: May2025 vid: 45 iid: 5 pid: 2579 pub: Springer Nature place: Dordrecht, <Blank> artinfo: ui: 186336180 186336180 186336180 10.1038/s41372-024-02188-8 186336180 ppf: 635 ppct: 7 formats: tig: atl: Bifidobacterium longum subsp infantis (EVC001) is associated with reduced incidence of necrotizing enterocolitis stage ≥2 and bloody stools in premature babies. aug: au: Sohn, Kristin Palacios, Victoria Clark, Reese affil: https://ror.org/01keh0577 Department of Pediatrics, University of Nevada School of Medicine, Reno, NV, USA sug: subj: Enterocolitis, Necrotizing Epidemiology Melena Epidemiology Enterocolitis, Necrotizing Prevention and Control Melena Prevention and Control Probiotics Therapeutic Use Protocols Bifidobacterium Infant, Premature Enteral Nutrition Drug Efficacy Medical Practice, Evidence-Based Human Male Female Infant, Newborn Funding Source Probiotics Administration and Dosage Prospective Studies Comparative Studies Inpatients Fisher's Exact Test Two-Tailed Test Descriptive Statistics Time Parenteral Nutrition Nevada Implementation Science Hospitals, Pediatric Intensive Care Units, Neonatal Critically Ill Patients Retrospective Design Record Review Data Analysis Software Patient Discharge Infant, Newborn: birth-1 month Male Female ab: Objective: To utilize an evidence-based probiotic protocol to achieve a 50% reduction in necrotizing enterocolitis (NEC) ≥ stage 2 and bloody stools. Study design: From January 2022 through September 2023, daily enteral Bifidobacterium longum ssp. infantis EVC001 (B. infantis EVC001) was administered to babies ≤ 33 6/7 weeks gestation until 36 weeks post menstrual age. Feeding tolerance and complications were compared to babies admitted during the prior two-year period. Fisher's Exact test was used to analyze proportional data and t test was used for continuous variables. Results: A total of 265 babies received EVC001, and a total of 277 babies formed the pre-probiotic cohort. Probiotic use was associated with decreased NEC ≥ stage 2 (p = 0.0058), reduced bloody stools (p < 0.0001), decreased time to full enteral feeds (p < 0.0001), and decreased total parenteral nutrition (TPN) days (p < 0.0001). Conclusion: Administration of B. infantis EVC001 was associated with a decrease in NEC, a decrease in bloody stools, and improvement in feeding tolerance in premature babies. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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