The relation between stress-related neural activity assessed by brain 18F-FDG-PET/CT and cardiovascular outcomes: a systematic review and meta-analysis.
Purpose: Our study aims to investigate the associations between stress-related neural activity (SNA), a quantified imaging biomarker in processing stress responses assessed by 18F-FDG-PET/CT, and cardiovascular (CV) outcomes based on available evidence. Methods: We searched databases from inception...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 52; no. 9; pp. 3366 - 3379 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jul2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186337151&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186337151 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Jul2025 vid: 52 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 186337151 184189158 10.1007/s00259-025-07217-y 186337151 ppf: 3366 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The relation between stress-related neural activity assessed by brain 18F-FDG-PET/CT and cardiovascular outcomes: a systematic review and meta-analysis. aug: au: Zhang, Xinyuan Li, Hengxin Niu, Xiaoyu Fu, Hang Xu, Rong Xu, Ke Yuan, Weifeng Xu, Ting Zeng, Jiangyao Zhou, Ziqi Song, Yu Zhang, Suming Guo, Yingkun Huang, Shan Xu, Huayan affil: https://ror.org/011ashp19 Department of Radiology, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, 20# Section 3 South Renmin Road, 610041, Chengdu, China sug: ab: Purpose: Our study aims to investigate the associations between stress-related neural activity (SNA), a quantified imaging biomarker in processing stress responses assessed by 18F-FDG-PET/CT, and cardiovascular (CV) outcomes based on available evidence. Methods: We searched databases from inception to December 1, 2024. Studies assessing the associations between SNA, as quantified by measuring FDG uptake values in the amygdala using 18F-FDG-PET/CT, and CV outcomes were included. Risk of bias was evaluated using the Newcastle–Ottawa Scale. Random-effects model was implemented for pooled effect sizes (ESs) and heterogeneity evaluation. Results: Ten studies with 3523 patients with 18F-FDG-PET/CT were included in our analysis (mean age: 58.5 years; 48.9% female). The ESs included in the analysis comprised hazard ratios (HR) and standardized mean differences (SMD). Among the studies reporting HR, 192 (11.5%) patients experienced composite adverse CV events during a mean follow-up period of 3.8 years. SNA significantly correlated with an increased risk of composite adverse CV events (pooled adjusted HR: 1.61, 95% confidence interval [CI]: 1.12, 2.32). Among the studies reported SMD, individuals experienced composite adverse CV events had significantly higher SNA values than those who did not (Hedges's g = 0.55, 95% CI: 0.14, 0.96). Conclusions: SNA, as a noninvasive quantified indicator of processing stress responses assessed by brain 18F-FDG-PET/CT, is associated with an increased risk of CV outcomes. Further research is warranted to validate these findings and to investigate the clinical utility of SNA across various demographic groups. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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