[18F]FDG PET imaging in the differentiation of cardiac masses: an updated systematic review and dual Meta-Analysis of diagnostic performance and parameter variability.
Introduction: Cardiac masses (CMs) encompass a heterogeneous group of benign, malignant, and pseudotumoural lesions, posing diagnostic challenges due to their rarity and varied aetiologies. Given the limitations of conventional imaging modalities in differentiating benign from malignant masses, [18F...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 52; no. 9; pp. 3379 - 3395 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jul2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186337152&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186337152 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Jul2025 vid: 52 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 186337152 184815067 10.1007/s00259-025-07289-w 186337152 ppf: 3379 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: [18F]FDG PET imaging in the differentiation of cardiac masses: an updated systematic review and dual Meta-Analysis of diagnostic performance and parameter variability. aug: au: Rizzo, Alessio Viccaro, Vincenzo Pavon, Anna Giulia Leo, Laura Anna Treglia, Giorgio affil: https://ror.org/04wadq306 Nuclear Medicine, Candiolo Cancer Institute, FPO–IRCCS, Turin, Italy sug: ab: Introduction: Cardiac masses (CMs) encompass a heterogeneous group of benign, malignant, and pseudotumoural lesions, posing diagnostic challenges due to their rarity and varied aetiologies. Given the limitations of conventional imaging modalities in differentiating benign from malignant masses, [18F]FDG PET/CT has emerged as a promising technique by providing metabolic information. This systematic review and meta-analysis aimed to evaluate the diagnostic performance of [18F]FDG PET/CT in characterising CMs and assess semi-quantitative parameters' role in distinguishing malignant from benign lesions. Methods: A systematic review and meta-analysis were conducted, including studies evaluating the diagnostic accuracy of [18F]FDG PET/CT in CMs. Sensitivity and specificity were pooled using a random-effects model, and a secondary analysis examined differences in SUVmax between malignant and benign lesions. Results: Fifteen studies enrolling 1114 patients met inclusion criteria. The pooled sensitivity and specificity of [18F]FDG PET/CT in detecting malignant CMs were 89.2% (95% CI: 85–92%) and 82.8% (95% CI: 78–87%), respectively. Malignant lesions exhibited significantly higher SUVmax values (range: 5.6–14.3) than benign masses (range: 1.1–5.3, p < 0.001). PET/CT proved particularly effective in cases with inconclusive findings from echocardiography, cardiac magnetic resonance, or CT, contributing to biopsy guidance and treatment planning. Conclusions: [18F]FDG PET/CT demonstrates robust diagnostic accuracy in differentiating benign from malignant cardiac masses, with SUVmax as a valuable malignancy marker. Its integration into multimodal imaging strategies enhances diagnostic certainty and optimises patient management. Despite these advantages, standardised imaging protocols and further multicentre prospective studies are warranted to refine its clinical application and validate its prognostic potential. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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