Texture Analysis of SPECT‐MPI Provides Prognostic Value in Improving Cardiac Resynchronization Therapy Response.
Background: Texture analysis (TA) is a powerful tool for extracting quantitative information, assessing myocardial heterogeneity, evaluating therapeutic efficacy, and predicting outcomes in heart disease. This study investigated whether TA based on gated single‐photon emission computed tomography my...
| Publicado en: | Pacing & Clinical Electrophysiology Vol. 48; no. 6; pp. 630 - 640 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jun2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186459916&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186459916 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01478389 4F8 jtl: Pacing & Clinical Electrophysiology issn: 01478389 maglogo: Y pubinfo: dt: Jun2025 vid: 48 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 186459916 185254753 186459916 186459916 10.1111/pace.15200 186459916 ppf: 630 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Texture Analysis of SPECT‐MPI Provides Prognostic Value in Improving Cardiac Resynchronization Therapy Response. aug: au: Jiang, Zhongwei Bu, Ju Zhao, Zhongqiang Li, Chunxiang Li, Dianfu Chen, Qiushi Qin, Huiyuan Wang, Cheng affil: Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing Jiangsu,, China sug: subj: Cardiac Resynchronization Therapy Treatment Outcomes Tomography, Emission-Computed, Single-Photon Myocardium Heart Function Tests Heart Diseases Prognosis Heart Failure Therapy Predictive Value of Tests Human Adult Middle Age Aged Quantitative Studies Univariate Statistics Logistic Regression Multivariate Analysis Male Female Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background: Texture analysis (TA) is a powerful tool for extracting quantitative information, assessing myocardial heterogeneity, evaluating therapeutic efficacy, and predicting outcomes in heart disease. This study investigated whether TA based on gated single‐photon emission computed tomography myocardial perfusion imaging (SPECT MPI) can enhance the prediction of response to cardiac resynchronization therapy (CRT). Methods: A total of 165 patients who underwent gated SPECT MPI and received CRT were enrolled in the study. Quantitative analysis of SPECT imaging generated 1225 TA features. Phase analysis of resting gated short‐axis SPECT myocardial perfusion images was utilized to assess left ventricular (LV) systolic and diastolic mechanical dyssynchrony (LVMD), including phase standard deviation (PSD), phase bandwidth (PBW), and entropy. Patients were categorized into CRT response and non‐response groups based on a ≥5% improvement in LV ejection fraction (LVEF) measured by echocardiography at the 6‐month follow‐up. Variables with a p‐value <0.05 in the univariate logistic regression analysis were incorporated into a backward stepwise multivariate logistic regression model for further analysis. Results: During follow‐up, 60.0% (99 of 165 patients) demonstrated a response to CRT. Univariate logistic regression analysis revealed that CRT response was significantly associated with N‐terminal pro‐brain natriuretic peptide (NT‐proBNP), non‐sustained ventricular tachycardia (NS‐VT), LV end‐diastolic diameter (LVEDD), LV end‐systolic diameter (LVESD), scar burden, systolic and diastolic PSD, PBW, entropy, and 51 TA parameters. In the backward stepwise multivariate regression analysis, inverse difference moment normalized (IDMN), NS‐VT, NT‐proBNP, diastolic PSD, and LVEDD emerged as independent predictors of CRT response. Conclusion: TA based on gated SPECT MPI provides independent prognostic predictor for CRT response in medically treated Heart failure patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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