Recent Insights Into Breast Cancer: Molecular Pathways, Epigenetic Regulation, and Emerging Targeted Therapies.
Breast cancer remains the most prevalent malignant tumor and a leading cause of cancer-related mortality among women worldwide. The disease comprises distinct molecular subtypes that influence tumor behavior, metastatic potential, and therapeutic response. This review presents recent advances in bre...
| Publicado en: | Breast Cancer: Basic & Clinical Research pp. 1 - 21 |
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| Autores principales: | , , , , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
7/13/2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186620292&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186620292 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11782234 B078 jtl: Breast Cancer: Basic & Clinical Research issn: 11782234 maglogo: Y pubinfo: dt: 7/13/2025 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 186620292 186620292 186620292 10.1177/11782234251355663 186620292 ppf: 1 ppct: 20 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Recent Insights Into Breast Cancer: Molecular Pathways, Epigenetic Regulation, and Emerging Targeted Therapies. aug: au: Maqsood, Quratulain Khan, Muhammad Umer Fatima, Tehreem Khalid, Sania Malik, Zaryab Ikram affil: Department of Food Science, Institute of Agricultural Sciences, University of the Punjab, Lahore, Pakistan sug: subj: Breast Neoplasms Physiopathology Epigenomics Research, Medical Pathology, Molecular Disease Progression Drug Resistance, Neoplasm Signal Transduction Receptors, Estrogen Physiology Epidermal Growth Factors Physiology Fibroblast Growth Factors Physiology Wnt Proteins Physiology Stem Cells Physiology Neoplastic Processes Histones Diagnostic Use MicroRNA Diagnostic Use Tumor Markers, Biological DNA Methyltransferases Diagnostic Use Breast Neoplasms Prognosis Breast Neoplasms Therapy Individualized Medicine T Lymphocytes Nanoparticle Drug Delivery System RNA, Circular Physiology ab: Breast cancer remains the most prevalent malignant tumor and a leading cause of cancer-related mortality among women worldwide. The disease comprises distinct molecular subtypes that influence tumor behavior, metastatic potential, and therapeutic response. This review presents recent advances in breast cancer research, with a particular emphasis on molecular and epigenetic mechanisms that contribute to tumor development, progression, and treatment resistance. Key signaling pathways—including estrogen receptor (ER), human epidermal growth factor receptor 2 (HER2), Notch, fibroblast growth factor receptor (FGFR), Wnt, and Hedgehog—play essential roles in the regulation of mammary stem cells and oncogenesis. Increasing evidence highlights the significance of epigenetic alterations such as DNA methylation, histone modifications, and microRNA expression in modulating gene activity relevant to tumor initiation and therapy resistance. Epigenetic molecular targets, including DNA methyltransferases (DNMTs), histone deacetylases (HDACs), EZH2, and non-coding RNAs, are gaining attention for their potential use in diagnosis, prognosis, and targeted therapy. Integration of multigene panel testing with epigenetic biomarkers has facilitated improved risk assessment and the development of individualized treatment strategies. Moreover, novel therapeutic approaches—such as CAR-T cell therapy, nanoparticle-mediated drug delivery systems, and the involvement of circular RNAs (circRNAs) in immune modulation—offer promising directions for precision medicine. This review consolidates current insights into the molecular and epigenetic landscape of breast cancer to provide a comprehensive understanding of disease complexity and to inform the development of more effective, personalized treatment options. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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