Allele-Specific Digital PCR Enhances Precision and Sensitivity in the Detection and Quantification of Copy Number Alterations in Heterogeneous DNA Samples.

Background While genetic analyses are vital in cancer diagnostics, measuring copy number (CN) alterations remains challenging, especially in heterogenous samples such as (liquid) biopsies. Using digital PCR, CN alterations are classically studied by comparing the abundances of the target of interest...

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Bibliographic Details

Published in:	Clinical Chemistry Vol. 71; no. 7; pp. 752 - 763
Main Authors:	Nell, Rogier J, Versluis, Mieke, Zoutman, Willem H, Luyten, Gregorius P M, Jager, Martine J, Velden, Pieter A van der
Format:	Journal Article
Published:	Oxford University Press / USA Jul2025
Online Access:	View this record in EBSCOhost