Mercury exposure triggers diabetes mellitus through a pancreatic beta cell endoplasmic reticulum stress mechanism.
Mercury the source of free radicals, can trigger the activation of ER stress can cause beta cell pancreas injuries and result in diabetes mellitus. There have been many studies on mercury toxicity in various organs, but there are still few scientific studies that examine the pathomechanism of diabet...
| Publicado en: | Revista Latinoamericana de Hipertensión Vol. 20; no. 6; pp. 410 - 417 |
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| Autores principales: | , , , , , , , , |
| Formato: | Artículo |
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Revista Latinoamericana de Hipertension
2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=186634412&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 186634412 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 18564550 FICN jtl: Revista Latinoamericana de Hipertensión issn: 18564550 maglogo: N pubinfo: dt: 2025 vid: 20 iid: 6 pid: 81901 pub: Revista Latinoamericana de Hipertension artinfo: ui: 186634412 10.5281/zenodo.15739647 ppf: 410 ppct: 7 formats: fmt: @attributes: type: P size: 1.1MB tig: atl: Mercury exposure triggers diabetes mellitus through a pancreatic beta cell endoplasmic reticulum stress mechanism. aug: au: Yuliana, Ida Triawanti Maulana, Irfan Prenggono, Muhammad Darwin Oktavianti, Ika Kustiyah Kania, Nia Fujiati Panghiyangani, Roselina Hasanah, Nurul affil: Medical Science Education Doctoral Programme, Faculty of Medicine and Health Sciences, Lambung Mangkurat University, South Kalimantan, Indonesia. Department of Biochemistry, Faculty of Medicine and Health Sciences, Lambung Mangkurat University, South Kalimantan, Indonesia. Departement of Nursing, Faculty of Medicine and Health Sciences, Lambung Mangkurat University, South Kalimantan, Indonesia. Department of Internal Medicine, Faculty of Medicine and Health Sciences, Lambung Mangkurat University, South Kalimantan, Indonesia. Department of Anatomical Pathology, Faculty of Medicine and Health Sciences, Lambung Mangkurat University, South Kalimantan, Indonesia. Department of Biomedics, Faculty of Medicine and Health Sciences, Lambung Mangkurat University, South Kalimantan, Indonesia. Department of Histology, Faculty of Medicine, Mulawarman University, North Kalimantan, Indonesia. su: Endoplasmic reticulum stress Pancreatic beta cells Mercury poisoning Etiology of diabetes Diabetes Mercury (Element) sug: subj: Endoplasmic reticulum stress Pancreatic beta cells Mercury poisoning Etiology of diabetes Diabetes Mercury (Element) keyword: Beta cells pancreas Ca2+ intracelluar ER stress GRP78 JNKp Mercury Células beta pancreáticas Estrés de RE Ión calcio Mercurio ab: Mercury the source of free radicals, can trigger the activation of ER stress can cause beta cell pancreas injuries and result in diabetes mellitus. There have been many studies on mercury toxicity in various organs, but there are still few scientific studies that examine the pathomechanism of diabetes mellitus caused by mercury through the endoplasmic reticulum stress. This study was conducted to investigate the triggering of the endoplasmic reticulum stress pathway due to mercury exposure in beta cell pancreas injury resulting diabetes mellitus. Research using randomized true laboratory experiment method with post-test control group design. The number of samples used was 28 Wistar rats. The research group consisted of 2 groups, control group was given aquadest ad libitum, and intervention group was given water contaminated with mercury per oral once a day (15 kg/WB). The treatment period was 14 consecutive days and on the 15th day, blood samples were taken. ER stress marker was assessed by examining Ca2+ count, expression levels of GRP 78 and JNKp; beta cell injuries were assessed by examining fasting blood sugar. The collected data were analyzed by independent t-test with 95% confidence level; significant if p>0. 05. 7373The study found that mercury exposure can trigger ER stress activation of pancreatic beta cells and cause impairment in their function in metabolising glucose, resulting in hyperglycaemia, which can lead to diabetes mellitus. Further research needs to be conducted to look for the involvement of higher-level cellular biomolecular mechanisms that could form the basis of specific therapies for mercury-induced diabetes mellitus. l mercurio la fuente de radicales libres puede desencadenar la activación del estrés del retículo endoplásmico puede causar lesiones en las células beta del páncreas y la diabetes mellitus resultante. Se han realizado muchos estudios sobre la toxicidad del mercurio en diversos órganos, pero todavía hay pocos estudios científicos que examinen el patomecanismo de la diabetes mellitus causada por el mercurio a través del estrés del retículo endoplásmico. Este estudio se llevó a cabo para investigar la activación de la vía del estrés del retículo endoplásmico debido a la exposición al mercurio en la lesión de la célula beta del páncreas resultante de la diabetes mellitus. La investigación utilizó el método de experimento de laboratorio real aleatorizado con diseño de grupo de control posterior a la prueba. El número de muestras utilizadas fue de 28 ratas Wistar. El grupo de investigación consistió en 2 grupos, el grupo de control recibió aquadest ad libitum, y el grupo de intervención recibió agua contaminada con mercurio por vía oral una vez al día (15 kg/WB). El periodo de tratamiento fue de 14 días consecutivos y el día 15 se tomaron muestras de sangre. Se evaluó el marcador de estrés RE examinando el recuento de Ca2+, los niveles de expresión de GRP 78 y JNKp; las lesiones de las células beta se evaluaron examinando la glucemia en ayunas. Los datos recogidos se analizaron mediante una prueba t independiente con un nivel de confianza del 95%; significativa si p>0,05. El estudio reveló que la exposición al mercurio puede desencadenar la activación del estrés de retorno de las células beta pancreáticas y alterar su función de metabolización de la glucosa, lo que provoca hiperglucemia y, por consiguiente, diabetes mellitus. Es necesario seguir investigando para buscar la implicación de mecanismos biomoleculares celulares de nivel superior que podrían constituir la base de terapias específicas para la diabetes mellitus inducida por mercurio. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Revista Latinoamericana de Hipertensión is the property of Revista Latinoamericana de Hipertension and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Revista Latinoamericana de Hipertensión holder: Revista Latinoamericana de Hipertension dt: @attributes: year: 2025 holdings: @attributes: islocal: N |
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