Representation in clinical trials sponsored by the United States Department of Veterans Affairs.
Background This study was conducted to determine whether demographic representation among U.S. Department of Veterans Affairs (VA)-sponsored trials differs from trials without VA sponsorship, with reference to VA patient demographics. Methods U.S. clinical trials registered between 1 March 2000 and...
| Publicado en: | Journal of Public Health Vol. 47; no. 2; pp. 203 - 207 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Jun2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186675794&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186675794 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17413842 1CA0 jtl: Journal of Public Health issn: 17413842 maglogo: N pubinfo: dt: Jun2025 vid: 47 iid: 2 pid: 622 pub: Oxford University Press / USA artinfo: ui: 186675794 186675794 186675794 10.1093/pubmed/fdaf003 186675794 ppf: 203 ppct: 4 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Representation in clinical trials sponsored by the United States Department of Veterans Affairs. aug: au: Gomez, Gabriela T Turner, Brandon E Steinberg, Jecca R Lam, Miranda B Wren, Sherry M affil: Department of Epidemiology, Johns Hopkins School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA sug: subj: Sociodemographic Factors United States Department of Veterans Affairs Clinical Trials Evaluation Research Support Research Subject Recruitment Human Treatment Outcomes Wilcoxon Rank Sum Test Wilcoxon Signed Rank Test Descriptive Statistics African Americans Veterans Health Services Administration Ethnic Groups Kruskal-Wallis Test Data Analysis Software Asians Hispanic Americans ab: Background This study was conducted to determine whether demographic representation among U.S. Department of Veterans Affairs (VA)-sponsored trials differs from trials without VA sponsorship, with reference to VA patient demographics. Methods U.S. clinical trials registered between 1 March 2000 and 1 February 2022 were stratified into VA and non-VA groups. Outcomes included the combined percentage of non-White participants in each trial and enrollment of each demographic subgroup. Trial strata were summarized using medians; Wilcoxon rank sum and one-sample signed rank tests were used to compare demographic representation between (i) VA and non-VA trials and (ii) VA trials and Veterans Health Administration (VHA) patient demographics, respectively. Results We identified 13,826 trials with available data, including 521 VA and 13,305 non-VA-sponsored trials. Median non-White enrollment was 68% greater in VA trials (P < .001) than in non-VA trials, driven by greater enrollment of Black participants (23.5% vs. 10.4%; P < .001). Black participant enrollment in VA trials exceeded representation among VHA beneficiaries (23.5% vs. 15.8%, P < .001). Conclusions This study highlights the increased Black representation in VA-sponsored clinical trials, which is greater than expected after accounting for VHA clinical population demographics. Partnership with the VA may represent a meaningful avenue for increasing Black representation in clinical trials. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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