Risk of clinically significant prostate cancer undercategorized by multiparametric magnetic resonance imaging.
Background: To investigative potential clinicopathological characteristics and imaging-related risk factors of clinically significant prostate cancer (csPCa) undercategorized in patients with negative or equivocal MRI. Methods: This retrospective study included 581 patients with pathologically confi...
| Published in: | Abdominal Radiology Vol. 50; no. 8; pp. 3827 - 3836 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Aug2025
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186678324&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186678324 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Aug2025 vid: 50 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 186678324 182386150 10.1007/s00261-024-04792-w 186678324 ppf: 3827 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Risk of clinically significant prostate cancer undercategorized by multiparametric magnetic resonance imaging. aug: au: Zhu, Wangshu Long, Haining Yu, Weibin Xiong, Yijia Fu, Caixia Zhao, Jungong Liu, Xiaohong affil: https://ror.org/0220qvk04 Department of Diagnostic and Interventional Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China sug: ab: Background: To investigative potential clinicopathological characteristics and imaging-related risk factors of clinically significant prostate cancer (csPCa) undercategorized in patients with negative or equivocal MRI. Methods: This retrospective study included 581 patients with pathologically confirmed csPCa (Gleason score ≥ 3 + 4), including 108 undercategorized csPCa and 473 detected csPCa. All patients underwent multiparametric MRI (mpMRI). The undercategorized csPCa was defined as a MRI result with PI-RADS ≤ 3. The clinicopathological characteristics and imaging-related factors were compared between the undercategorized group(Group A) (PI-RADS 1–3) and detected group (Group B) (PI-RADS 4–5). Results: The age, total PSA levels, PSAD, free PSA, prostate imaging quality (PI-QUAL) scores, and Gleason scores were significantly lower in the Group A than Group B. The lesions were larger and involved in peripheral and transition zones in the Group B. A significant difference in the second reading opinion. Age (odds ratio [OR], 0.94), PSAD (OR, 0.09), and PI-QUAL scores (OR, 0.25) were significantly associated with the undercategorized csPCa. The rate of undercategorized csPCa with these three risk factors (age, PSAD, and PI-QUAL scores of < 71, < 0.355, and < 3, respectively) was 68.62%. The lack of zoomed-DWI resulted in lower PI-QUAL scores. Finally, the probability of undercategorized csPCa without zoomed DWI was 3.186 times higher than that with zoomed DWI when the PSAD ratio is lower than 0.355. Conclusions: Low image quality, younger age, and lower PSAD contribute to csPCa undercategorized by mpMRI. Moreover, the use of zoomed DWI decreased undercategorized csPCa by improving PI-QUAL scores of MRI images. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|