Predicting response to initial chemotherapy in pediatric lymphoma using a semiquantitative contrast enhanced CT (CECT)-based abdomino-thoracic score: a pilot prospective observational study.
Background: There is a lack of staging systems in pediatric lymphoma to quantify the burden of the disease based on the anatomical extent of lymph nodal distribution. Purpose: To evaluate the utility of a CECT-based semiquantitative lymph nodal scoring system in predicting histopathological type of...
| Published in: | Abdominal Radiology Vol. 50; no. 8; pp. 3868 - 3876 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Aug2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186678348&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186678348 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Aug2025 vid: 50 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 186678348 182790284 10.1007/s00261-025-04821-2 186678348 ppf: 3868 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Predicting response to initial chemotherapy in pediatric lymphoma using a semiquantitative contrast enhanced CT (CECT)-based abdomino-thoracic score: a pilot prospective observational study. aug: au: Kumar, Ishan Sonker, Shashank Aggarwal, Priyanka Gupta, Vineeta Shukla, Ram Chandra Verma, Ashish affil: https://ror.org/04y75dx46 Department of Radiodiagnosis and Imaging, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India sug: ab: Background: There is a lack of staging systems in pediatric lymphoma to quantify the burden of the disease based on the anatomical extent of lymph nodal distribution. Purpose: To evaluate the utility of a CECT-based semiquantitative lymph nodal scoring system in predicting histopathological type of childhood lymphoma and response to initial chemotherapy. Materials and methods: Pre-treatment CECT of abdomen and thorax was performed in children with lymphoma and a Checklist-based reporting template was used to report the lymph nodal involvement. Based on the distribution of lymph nodes, a semi-quantitative scoring system was developed to cover all the locations of thorax and abdomen. Anatomical semiquantitative scoring was done for thorax (score 0–10), abdomen (scores 0–10), and a combined thoraco-abdominal score (0–20) was calculated. Also, the mean scores were compared in patients with complete response(CR) and Non-complete response(NCR) to primary treatment. Decrease in size of all the pathological nodes to < 10 mm in short axis and < 15 mm in long axis was defined as CR. Results: Fifty patients were included with 35 cases of Hodgkin Lymphoma(HL) and 15 cases of Non-Hodgkin Lymphoma(NHL). Mean abdominal, thoracic, and combined lymph nodal scores were significantly lower in the pre-treatment scan in children with HL (3.5 ± 2.3, 3.3 ± 1.75,and6.89 ± 3.54) compared to NHL (4.8 ± 2.1,5.2 ± 2.8,and10.0 ± 3.96). The mean abdominal, thoracic, and combined lymph nodal scores in the pre-treatment scan was significantly higher in NCR group. Conclusion: The lymph nodal burden, estimated by semiquantitative abdominal and thoracic scores is significantly higher in lymphoma patients with non-complete response. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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