Childhood, adulthood, and cumulative traumatic events experienced from childhood to adulthood and dementia risk: a population-based cohort study.
Aim: We aim to examine the association of traumatic events experienced in childhood, adulthood, and cumulative traumatic events experienced from childhood to adulthood, with the risk of all-cause dementia, including Alzheimer's disease (AD) and vascular dementia (VD), while considering the roles of...
| Publicado en: | Journal of Public Health: From Theory to Practice (2198-1833) Vol. 33; no. 8; pp. 1625 - 1636 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Springer Nature
Aug2025
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=186838147&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 186838147 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 21981833 NENI jtl: Journal of Public Health: From Theory to Practice (2198-1833) issn: 21981833 maglogo: N pubinfo: dt: Aug2025 vid: 33 iid: 8 pid: 237 pub: Springer Nature artinfo: ui: 186838147 10.1007/s10389-023-02140-8 ppf: 1625 ppct: 11 formats: tig: atl: Childhood, adulthood, and cumulative traumatic events experienced from childhood to adulthood and dementia risk: a population-based cohort study. aug: au: Xie, Ziwei Li, Meiling Sun, Huizi Zhou, Chunmiao Fu, Chunying Wang, Qi Dong, Caiyun Hao, Wenting Zhen, Xuemei Zhu, Dongshan affil: https://ror.org/0207yh398 Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China https://ror.org/0207yh398 Centre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China https://ror.org/0207yh398 NHC Key Lab of Health Economics and Policy Research (Shandong University), 250012, Jinan, China su: China Uk Biobank Ltd. Sex crimes Sex distribution Emotional trauma Psychological abuse Sociodemographic factors Adverse childhood experiences Disease risk factors Alzheimer's disease risk factors Dementia risk factors Risk assessment Research funding Vascular dementia Descriptive statistics Longitudinal method Comparative studies Confidence intervals Proportional hazards models sug: subj: Sex crimes Sex distribution Emotional trauma Psychological abuse Sociodemographic factors Adverse childhood experiences Disease risk factors China Uk Biobank Ltd. Alzheimer's disease risk factors Dementia risk factors Risk assessment Research funding Vascular dementia Descriptive statistics Longitudinal method Comparative studies Confidence intervals Proportional hazards models keyword: Adulthood Childhood Dementia Medical and Health Sciences Public Health and Health Services Traumatic events Adulthood Childhood Dementia Medical and Health Sciences Public Health and Health Services Traumatic events ab: Aim: We aim to examine the association of traumatic events experienced in childhood, adulthood, and cumulative traumatic events experienced from childhood to adulthood, with the risk of all-cause dementia, including Alzheimer's disease (AD) and vascular dementia (VD), while considering the roles of sex. Subject and methods: We used data from the UK Biobank cohort study and 145,558 participants were included. Frequency of traumatic events (including emotional abuse, physical abuse, and sexual abuse) experienced in childhood and adulthood were collected. Cumulative number and type of traumatic events experienced from childhood to adulthood were also calculated. We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CI) for the association between traumatic events and risk of all-cause dementia. Sex-specific associations were also analyzed. Results: Compared to people who did not experience traumatic events in their life course, those who often experienced emotional, physical, and sexual abuse in childhood were associated with a higher risk of all-cause dementia, with HRs (95% CI) of 2.23 (1.34, 3.71), 3.16 (1.81, 5.53), and 3.23 (1.52, 6.89), respectively. Corresponding HRs (95% CI) in people who experienced traumatic events in adulthood were 1.42 (1.11, 1.82), 1.96 (0.97, 3.98), and 3.13 (1.18, 8.27), respectively. After cumulative type of traumatic events were calculated from childhood to adulthood, we found that people who experienced both emotional and physical abuse in childhood had the highest risk of all-cause dementia in later life with HRs (95% CI) of 1.94 (1.00–3.78). Conclusion: Traumatic events experienced in both childhood and adulthood were related to an increased risk of dementia. People who experienced both emotional and physical abuse in childhood had the highest risk of all-cause dementia. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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