Application Value and Clinical Correlation of Ultrasonic Shear Wave Elastography in Chronic Kidney Disease.
Objective: This study is the first attempt to apply shear wave elastography (SWE) technology to the dynamic evaluation of patients with chronic kidney disease (CKD), aiming to fill the evidence gap of this technology in this clinical scenario. Methods: This case‐control study enrolled 75 biopsy‐conf...
| Publicado en: | Echocardiography Vol. 42; no. 7; pp. 1 - 10 |
|---|---|
| Autores principales: | , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jul2025
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186884318&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186884318 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07422822 GSE jtl: Echocardiography issn: 07422822 maglogo: Y pubinfo: dt: Jul2025 vid: 42 iid: 7 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 186884318 186884318 186884318 10.1111/echo.70231 186884318 ppf: 1 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Application Value and Clinical Correlation of Ultrasonic Shear Wave Elastography in Chronic Kidney Disease. aug: au: Guo, Li Zhang, Ya‐Pu Li, Jian‐Dong Ran, Lei Zhou, Xuan Gao, Yan Wu, Xiao‐Xi Li, Jing affil: Department of Nephrology, Affiliated Hospital of HeBei University, Baoding Hebei,, China sug: subj: Renal Insufficiency, Chronic Physiopathology Renal Insufficiency, Chronic Ultrasonography Kidney Physiopathology Kidney Ultrasonography Ultrasonography Methods Human Male Female Adult Middle Age Case Control Studies Biopsy Elasticity Kidney Anatomy and Histology Reproducibility of Results Sensitivity and Specificity Disease Progression Decision Making, Clinical Funding Source Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Objective: This study is the first attempt to apply shear wave elastography (SWE) technology to the dynamic evaluation of patients with chronic kidney disease (CKD), aiming to fill the evidence gap of this technology in this clinical scenario. Methods: This case‐control study enrolled 75 biopsy‐confirmed CKD patients (observation group) and 20 healthy adults (control group). Renal morphological parameters (length, diameter, parenchymal thickness) were obtained via two‐dimensional ultrasonography. Under SWE mode, three consecutive measurements of Young's modulus (Emean, Emax, Emin) were performed at the right renal lower pole cortex, with the mean value used for analysis. Results: Key findings included: Significant reductions in renal length (9.8±1.2 cm vs. 11.5±0.9 cm, p < 0.05) and parenchymal thickness (1.2±0.3 cm vs. 1.8±0.2 cm, p < 0.05) in CKD patients versus controls; Elevated elasticity parameters in CKD group (Emean: 24.7±5.1 kPa vs. 12.3±2.8 kPa; Emax: 38.9±7.2 kPa vs. 16.1±3.5 kPa; Emin: 15.2±3.8 kPa vs. 8.7±1.9 kPa; all p < 0.05); Stage‐dependent variations: CKD Stage 3–4 exhibited 32% higher Emean than Stage 1–2 (p < 0.01); Diagnostic performance metrics: Emax showed superior specificity (92.1% vs. 85.6% for Emean, 78.3% for Emin), Emin demonstrated higher sensitivity (89.4% vs. 82.7% for Emax, 79.5% for Emean); Strong correlations between SWE parameters and disease progression (r = 0.82 for Emax vs. eGFR, P<0.001). Conclusion: SWE provides a reliable non‐invasive approach for quantifying renal elasticity alterations, demonstrating excellent diagnostic accuracy in CKD staging. The complementary performance of Emax (specificity) and Emin (sensitivity) suggests their combined use could optimize clinical decision‐making. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|