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Corneal Topography Parameters and Tear Film Break-up Characteristics in Keratoconus Patients.

Aims/Background Previous studies have found that keratoconus (KC) patients are highly susceptible to dry eye disease (DED); however, the specific relationship between KC and DED has not been thoroughly investigated. This study aims to investigate the corneal topography parameters and tear film (TF)...

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Published in:British Journal of Hospital Medicine (17508460) Vol. 86; no. 7; pp. 1 - 17
Main Authors: Wu, Dan, Hong, Jiaxu, Wu, Suqian, Xu, Jianjiang
Format: diagnostic images pictorial research tables/charts Journal Article
Published: Mark Allen Holdings Limited Jul2025
Online Access:View this record in EBSCOhost
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      jtl: British Journal of Hospital Medicine (17508460)
      issn: 17508460
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      dt: Jul2025
      vid: 86
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      pub: Mark Allen Holdings Limited
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        10.12968/hmed.2024.0825
        186885829
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        atl: Corneal Topography Parameters and Tear Film Break-up Characteristics in Keratoconus Patients.
      aug:
        au:
          Wu, Dan
          Hong, Jiaxu
          Wu, Suqian
          Xu, Jianjiang
        affil: Department of Ophthalmology and Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China
      sug:
        subj:
          Corneal Topography
          Keratoconus Physiopathology
          Keratoconus Complications
          Dry Eye Syndromes Etiology
          Tears
          Cornea Physiopathology
          Dry Eye Syndromes Diagnosis
          Human
          Funding Source
          China
          Male
          Female
          Child
          Adolescence
          Adult
          Case Control Studies
          Cross Sectional Studies
          Diagnosis, Eye
          Cornea Physiology
          Descriptive Statistics
          Data Analysis Software
          Confidence Intervals
          Odds Ratio
          Keratoconus Epidemiology
          Dry Eye Syndromes Epidemiology
          Chi Square Test
          Questionnaires
          Child: 6-12 years
          Adolescent: 13-18 years
          Adult: 19-44 years
          Male
          Female
      ab: Aims/Background Previous studies have found that keratoconus (KC) patients are highly susceptible to dry eye disease (DED); however, the specific relationship between KC and DED has not been thoroughly investigated. This study aims to investigate the corneal topography parameters and tear film (TF) break-up characteristics in KC patients with and without DED. Methods This cross-sectional, single-masked study consisted of 44 KC patients (44 eyes; KC group) and 31 normal individuals (31 eyes; control group). All the participants were recruited from the Department of Ophthalmology and Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University (Shanghai, China) from February 2018 to January 2023. They underwent a routine ophthalmic examination, ocular surface disease index questionnaire, corneal fluorescein staining, and Schirmer I test. Additionally, the participants were examined using the Oculus Keratograph® (OCULUS Inc., Arlington, TX, USA) to determine their corneal topography, noninvasive TF break-up time, and TF break-up point. The KC patients were further divided into KC-DED and KC-non-DED subgroups to analyze the impact of KC on TF characteristics and the incidence of DED. Finally, the relationship between the TF break-up point and the maximum cornea curvature quadrant was investigated. Results In the KC group, 21 patients (21 eyes; 47.72%) were diagnosed with DED. The KC-DED and KC-non-DED subgroups exhibited significantly different maximum keratometry (Kmax, p = 0.021), index of surface variance (p = 0.048), and index of height decentration (p = 0.011) values. The logistic model showed a strong correlation between KC-DED incidence and Kmax value (odds ratio = 1.169, 95% confidence interval: 1.020–1.340, p = 0.025). Moreover, the occurrence of DED increased from 36.67% to 71.43% when the Kmax was >52.00 D (χ2 = 4.623, p = 0.031). Furthermore, TF was more prone to break-up in the maximum corneal curvature quadrant in the KC group than in the control group (p < 0.001). Conclusion TF should be closely monitored in KC patients, as they are highly prone to DED incidence (Kmax >52.00 D) and experience initial TF break-up in the maximum corneal curvature quadrant.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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