Comparison of GFR estimation equations using creatinine, cystatin C, and their combination in pediatric hematology–oncology: no single equation is superior across subgroups.
Background: Accurate assessment of renal function is essential in treating pediatric patients dosed with nephrotoxic chemotherapy. The validity of the bedside Schwartz, 5-covariate St. Jude (5SJ), CKiD-CysC-U25, combined Cr-CysC-based CysPed, and the serum creatinine-BUN-cystatin C-based CKiD (CKiD...
| Publicado en: | Pediatric Nephrology Vol. 40; no. 9; pp. 2907 - 2918 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186910314&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186910314 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Sep2025 vid: 40 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 186910314 184669723 186910314 186910314 10.1007/s00467-025-06765-7 186910314 ppf: 2907 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Comparison of GFR estimation equations using creatinine, cystatin C, and their combination in pediatric hematology–oncology: no single equation is superior across subgroups. aug: au: Phillips, Katelyn J. Sun, Yilun Tang, Li Pappas, Andrew Cross, Shane J. Pauley, Jennifer L. McCormick, John Molinelli, Alejandro R. Bissler, John J. Christensen, Anthony M. Stewart, Clinton F. affil: https://ror.org/02r3e0967 Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA sug: subj: Data Analysis, Statistical Glomerular Filtration Rate Creatinine Blood Cystatin C Blood Hematology Oncology Pediatrics Human Male Female Infant Child, Preschool Child Adolescence Retrospective Design Record Review Technetium Carboplatin Funding Source Infant: 1-23 months Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years Male Female ab: Background: Accurate assessment of renal function is essential in treating pediatric patients dosed with nephrotoxic chemotherapy. The validity of the bedside Schwartz, 5-covariate St. Jude (5SJ), CKiD-CysC-U25, combined Cr-CysC-based CysPed, and the serum creatinine-BUN-cystatin C-based CKiD (CKiD Cr-CysC) equations were evaluated in pediatric hematology and oncology patients. Methods: A retrospective analysis was conducted comparing estimated glomerular filtration rate (eGFR) to measured GFR (mGFR) obtained from technetium- 99 m diethylenetriaminepentaacetic acid (99 mTc-DTPA) clearance between January 2016 and May 2022. The influence of corticosteroid use and inflammation in our patient population was evaluated for effect on serum cystatin C (CysC) concentrations and mGFR. Results: All equations agreed within 2 SD of the mean difference with mGFR, but the 5SJ equation had the smallest bias followed closely by the CysPed equation. Overall accuracy (P30) was assessed, and the 5SJ, CKiD Cr-CysC, CysPed, and CKiD-Cys-U25 exhibited comparable performance. In our patient population, we did not observe an effect of corticosteroids (cumulative dosage of > 0.5 mg/kg within the past 14 days) or the presence of inflammation (CRP > 1.2 mg/L) on cystatin C concentrations or mGFR. Conclusions: In our pediatric hematology and oncology patient population, no one estimating equation demonstrated superior accuracy and bias overall and in all subgroups. Neither corticosteroid use nor elevated CRP influenced serum CysC concentrations or eGFR. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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