Acute nicotine vapor attenuates sensorimotor gating deficits in HIV-1 transgenic rats.
Rationale: Despite improved life expectancy of people with HIV (PWH), HIV-associated neurocognitive impairment (NCI) persists, alongside deficits in sensorimotor gating and neuroinflammation. PWH exhibit high smoking rates, possibly due to neuroprotective, anti-inflammatory, and cognitive-enhancing...
| Publicado en: | Psychopharmacology Vol. 242; no. 8; pp. 1783 - 1797 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186910335&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186910335 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Aug2025 vid: 242 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 186910335 183230347 10.1007/s00213-025-06761-7 186910335 ppf: 1783 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Acute nicotine vapor attenuates sensorimotor gating deficits in HIV-1 transgenic rats. aug: au: Jha, Neal A. Ayoub, Samantha M. Flesher, M. Melissa Morton, Kathleen Sikkink, Megan Guglielmo, Giordano de Khokhar, Jibran Y. Minassian, Arpi Brody, Arthur L. Young, Jared W. affil: https://ror.org/05t99sp05 Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, CA, USA sug: ab: Rationale: Despite improved life expectancy of people with HIV (PWH), HIV-associated neurocognitive impairment (NCI) persists, alongside deficits in sensorimotor gating and neuroinflammation. PWH exhibit high smoking rates, possibly due to neuroprotective, anti-inflammatory, and cognitive-enhancing effects of nicotine, suggesting potential self-medication. Objectives: Here, we tested the effects of acute nicotine vapor exposure on translatable measures of sensorimotor gating and exploratory behavior in the HIV-1 transgenic (HIV-1Tg) rat model of HIV. Methods: Male and female HIV-1Tg (n = 28) and F344 control rats (n = 29) were exposed to acute nicotine or vehicle vapor. Sensorimotor gating was assessed using prepulse inhibition (PPI) of the acoustic startle response, and exploratory behavior was evaluated using the behavioral pattern monitor (BPM). Results: Vehicle-treated HIV-1Tg rats exhibited PPI deficits at low prepulse intensities compared to F344 controls, as seen previously. No PPI deficits were observed in nicotine-treated HIV-1Tg rats, however. Nicotine vapor increased locomotor activity across genotypes. Cotinine analyses confirmed comparable levels of the primary metabolite of nicotine across genotypes. Conclusions: Previous findings of PPI deficits in HIV-1Tg rats were replicated and, importantly, attenuated by acute nicotine vapor administration. Evidence for similar cotinine levels suggest a nicotine-specific effect in HIV-1Tg rats. Therefore, acute nicotine administration may be beneficial for attenuating sensorimotor deficits in PWH. Future studies should determine the long-term effects of nicotine vapor on similar HIV/NCI-relevant behaviors. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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