The psychedelic (−)-2,5-dimethoxy-4-iodoamphetamine [(−)-DOI] demonstrates efficacy in reducing cocaine reward and motivation in male rats.

Rationale and objectives: Overdose fatalities involving cocaine continue to rise with over 5.3 million cocaine users reported in the United States in 2022. The abuse liability of cocaine is reliant upon inhibition of dopamine (DA) reuptake and consequent increase in DA efflux in meso-corticolimbic c...

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Bibliographic Details

Published in:	Psychopharmacology Vol. 242; no. 8; pp. 1833 - 1845
Main Authors:	Salinsky, Leah M., Merritt, Christina R., Garcia, Erik J., Fox, Robert G., Zamora, Joshua C., Anastasio, Noelle C., Cunningham, Kathryn A.
Format:	Journal Article
Published:	Springer Nature Aug2025
Online Access:	View this record in EBSCOhost